Computational psychiatry: from synapses to sentience

• Published in: Molecular psychiatry Vol. 28; no. 1; pp. 256 - 268
• Main Author: Friston, Karl
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2023; Nature Publishing Group
• Subjects: 631/443; 692/53; Behavioral Sciences; Biological Psychology; Brain; Chronic pain; Classification; Cognitive ability; Computational neuroscience; Computer Simulation; Epilepsy; Expert Review; Humans; Medicine; Medicine & Public Health; Mental disorders; Nervous system; Neural networks; Neurodegenerative diseases; Neurosciences; Pharmacotherapy; Phenotyping; Post traumatic stress disorder; Psychiatry; Psychiatry - methods; Psychopathology; Schizophrenia; Synapses

This review considers computational psychiatry from a particular viewpoint: namely, a commitment to explaining psychopathology in terms of pathophysiology. It rests on the notion of a generative model as underwriting (i) sentient processing in the brain, and (ii) the scientific process in psychiatry...