Plasmonic silver nanoshells for drug and metabolite detection

• Published in: Nature communications Vol. 8; no. 1; pp. 220 - 10
• Main Authors: Huang, Lin, Wan, Jingjing, Wei, Xiang, Liu, Yu, Huang, Jingyi, Sun, Xuming, Zhang, Ru, Gurav, Deepanjali D., Vedarethinam, Vadanasundari, Li, Yan, Chen, Ruoping, Qian, Kun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.08.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/61/320; 639/301/357/354; 639/638/11/296; 692/53/2421; Biomarkers; Blood; Brain Diseases - cerebrospinal fluid; Brain Diseases - diagnosis; Cerebrospinal fluid; Clinical Laboratory Techniques; Glucose - cerebrospinal fluid; Humanities and Social Sciences; Humans; Infections - cerebrospinal fluid; Infections - diagnosis; Ionization; Mass spectrometry; Metabolites; multidisciplinary; Nanoparticles; Nanoshells - chemistry; Pharmaceutical Preparations - blood; Pharmaceutical Preparations - cerebrospinal fluid; Pharmacokinetics; Plasmonics; Postoperative Complications - cerebrospinal fluid; Postoperative Complications - diagnosis; Sample preparation; Science; Science (multidisciplinary); Silver

In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance...