Plasmonic silver nanoshells for drug and metabolite detection

In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance...

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Published in	Nature communications Vol. 8; no. 1; pp. 220 - 10
Main Authors	Huang, Lin, Wan, Jingjing, Wei, Xiang, Liu, Yu, Huang, Jingyi, Sun, Xuming, Zhang, Ru, Gurav, Deepanjali D., Vedarethinam, Vadanasundari, Li, Yan, Chen, Ruoping, Qian, Kun
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 09.08.2017 Nature Publishing Group Nature Portfolio
Subjects	631/61/320 639/301/357/354 639/638/11/296 692/53/2421 Biomarkers Blood Brain Diseases - cerebrospinal fluid Brain Diseases - diagnosis Cerebrospinal fluid Clinical Laboratory Techniques Glucose - cerebrospinal fluid Humanities and Social Sciences Humans Infections - cerebrospinal fluid Infections - diagnosis Ionization Mass spectrometry Metabolites multidisciplinary Nanoparticles Nanoshells - chemistry Pharmaceutical Preparations - blood Pharmaceutical Preparations - cerebrospinal fluid Pharmacokinetics Plasmonics Postoperative Complications - cerebrospinal fluid Postoperative Complications - diagnosis Sample preparation Science Science (multidisciplinary) Silver
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Abstract	In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO 2 @Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics. Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid.
AbstractList	In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO @Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics.Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid. In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO 2 @Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics. Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid. In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO2@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics. In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO2@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics.Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid.In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO2@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics.Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid. In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO 2 @Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics. Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid.
ArticleNumber	220
Author	Chen, Ruoping Liu, Yu Qian, Kun Sun, Xuming Li, Yan Wan, Jingjing Zhang, Ru Vedarethinam, Vadanasundari Huang, Lin Gurav, Deepanjali D. Wei, Xiang Huang, Jingyi
Author_xml	– sequence: 1 givenname: Lin surname: Huang fullname: Huang, Lin organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 2 givenname: Jingjing surname: Wan fullname: Wan, Jingjing organization: Department of Chemistry, Shanghai University – sequence: 3 givenname: Xiang surname: Wei fullname: Wei, Xiang organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 4 givenname: Yu surname: Liu fullname: Liu, Yu organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 5 givenname: Jingyi surname: Huang fullname: Huang, Jingyi organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 6 givenname: Xuming surname: Sun fullname: Sun, Xuming organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 7 givenname: Ru surname: Zhang fullname: Zhang, Ru organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 8 givenname: Deepanjali D. surname: Gurav fullname: Gurav, Deepanjali D. organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 9 givenname: Vadanasundari surname: Vedarethinam fullname: Vedarethinam, Vadanasundari organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 10 givenname: Yan surname: Li fullname: Li, Yan organization: Institute of Biophysics Key Laboratory of Interdisciplinary Research, Chinese Academy of Sciences – sequence: 11 givenname: Ruoping surname: Chen fullname: Chen, Ruoping email: rubinchen@126.com organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University – sequence: 12 givenname: Kun surname: Qian fullname: Qian, Kun email: k.qian@sjtu.edu.cn organization: School of Biomedical Engineering, Children’s Hospital of Shanghai, and Med-X Research Institute, Shanghai Jiao Tong University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28790311$$D View this record in MEDLINE/PubMed
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Copyright	The Author(s) 2017 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Snippet	In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical... Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach...
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SubjectTerms	631/61/320 639/301/357/354 639/638/11/296 692/53/2421 Biomarkers Blood Brain Diseases - cerebrospinal fluid Brain Diseases - diagnosis Cerebrospinal fluid Clinical Laboratory Techniques Glucose - cerebrospinal fluid Humanities and Social Sciences Humans Infections - cerebrospinal fluid Infections - diagnosis Ionization Mass spectrometry Metabolites multidisciplinary Nanoparticles Nanoshells - chemistry Pharmaceutical Preparations - blood Pharmaceutical Preparations - cerebrospinal fluid Pharmacokinetics Plasmonics Postoperative Complications - cerebrospinal fluid Postoperative Complications - diagnosis Sample preparation Science Science (multidisciplinary) Silver
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Title	Plasmonic silver nanoshells for drug and metabolite detection
URI	https://link.springer.com/article/10.1038/s41467-017-00220-4 https://www.ncbi.nlm.nih.gov/pubmed/28790311 https://www.proquest.com/docview/1927177188 https://www.proquest.com/docview/1927594958 https://pubmed.ncbi.nlm.nih.gov/PMC5548796 https://doaj.org/article/a92e3a1d876640c5b00846f49fee7c3b
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