Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo

• Published in: Cell reports (Cambridge) Vol. 19; no. 11; pp. 2345 - 2356
• Main Authors: Hirche, Christoph, Frenz, Theresa, Haas, Simon F., Döring, Marius, Borst, Katharina, Tegtmeyer, Pia-K., Brizic, Ilija, Jordan, Stefan, Keyser, Kirsten, Chhatbar, Chintan, Pronk, Eline, Lin, Shuiping, Messerle, Martin, Jonjic, Stipan, Falk, Christine S., Trumpp, Andreas, Essers, Marieke A.G., Kalinke, Ulrich
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.06.2017; Elsevier
• Subjects: Animals; bone marrow transplantation; Cell Cycle; Cell Proliferation; hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Infection - virology; inflammatory cytokines; Mice; quiescence; Signal Transduction; stem cell activation; stem cell function; systemic inflammation; transplant complications; virus infections; systemic inflammation; transplant complications; stem cell activation; cell cycle; stem cell function; quiescence; inflammatory cytokines; hematopoietic stem cells; bone marrow transplantation; virus infections

Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCM...