A cohort autopsy study defines COVID-19 systemic pathogenesis

• Published in: Cell research Vol. 31; no. 8; pp. 836 - 846
• Main Authors: Yao, Xiao-Hong, Luo, Tao, Shi, Yu, He, Zhi-Cheng, Tang, Rui, Zhang, Pei-Pei, Cai, Jun, Zhou, Xiang-Dong, Jiang, Dong-Po, Fei, Xiao-Chun, Huang, Xue-Quan, Zhao, Lei, Zhang, Heng, Wu, Hai-Bo, Ren, Yong, Liu, Zhen-Hua, Zhang, Hua-Rong, Chen, Cong, Fu, Wen-Juan, Li, Heng, Xia, Xin-Yi, Chen, Rong, Wang, Yan, Liu, Xin-Dong, Yin, Chang-Lin, Yan, Ze-Xuan, Wang, Juan, Jing, Rui, Li, Tai-Sheng, Li, Wei-Qin, Wang, Chao-Fu, Ding, Yan-Qing, Mao, Qing, Zhang, Ding-Yu, Zhang, Shu-Yang, Ping, Yi-Fang, Bian, Xiu-Wu
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.08.2021; Nature Publishing Group
• Subjects: 13/51; 14/63; 38/77; 631/250; 631/80/304; Aged; Aged, 80 and over; Autopsies; Autopsy; Biomedical and Life Sciences; Blood; Cell Biology; Cell proliferation; China; Cohort Studies; Coronaviruses; COVID-19; COVID-19 - pathology; COVID-19 - virology; Critical Illness; Female; Fibrosis; Hospitalization; Humans; Kidney - pathology; Kidney - virology; Leukocytes, Mononuclear - pathology; Leukocytes, Mononuclear - virology; Life Sciences; Lung - pathology; Lung - virology; Lung diseases; Lungs; Macrophages; Male; Middle Aged; Monocytes; Organotropism; Organs; Pathogenesis; Pathogenicity; Pathogens; Patients; RNA, Viral - metabolism; SARS-CoV-2 - genetics; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome coronavirus 2; Spleen - pathology; Spleen - virology; Trachea - pathology; Trachea - virology; Viral diseases; China

Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown. We profiled 26 COVID-19 autopsy cases from four cohort...