Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2

• Published in: npj vaccines Vol. 6; no. 1; pp. 156 - 13
• Main Authors: Lassaunière, Ria, Polacek, Charlotta, Gram, Gregers J., Frische, Anders, Tingstedt, Jeanette Linnea, Krüger, Maren, Dorner, Brigitte G., Cook, Anthony, Brown, Renita, Orekov, Tatyana, Putmon-Taylor, Tammy, Campbell, Tracey-Ann, Greenhouse, Jack, Pessaint, Laurent, Andersen, Hanne, Lewis, Mark G., Fomsgaard, Anders
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/590/1991; 631/326/596/4130; 631/61/24/590/1991; Biomedical and Life Sciences; Biomedicine; COVID-19; COVID-19 vaccines; Deoxyribonucleic acid; DNA; Immunization; Immunogenicity; Infectious Diseases; Medical Microbiology; Public Health; Severe acute respiratory syndrome coronavirus 2; Vaccine; Vaccines; Virology

New generation plasmid DNA vaccines may be a safe, fast and simple emergency vaccine platform for preparedness against emerging viral pathogens. Applying platform optimization strategies, we tested the pre-clinical immunogenicity and protective effect of a candidate DNA plasmid vaccine specific for...