Enyne diketones as substrate in asymmetric Nazarov cyclization for construction of chiral allene cyclopentenones

• Published in: Nature communications Vol. 13; no. 1; pp. 3146 - 11
• Main Authors: Tang, Shengbiao, Zhang, Peng, Shao, Ying, Sun, Jiangtao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.06.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/935; 639/638/549/972; 639/638/77/883; Alkynes; Allene; Asymmetric synthesis; Asymmetry; Catalysis; Diketones; Enantiomers; Humanities and Social Sciences; Isomerization; multidisciplinary; Relay; Rhodium; Science; Science (multidisciplinary); Stereoselectivity; Substrates; Synthesis

The Nazarov cyclization is one of the most powerful tools for the stereoselective synthesis of various cyclopentenone scaffolds. Therefore, developing the new classes substrate of Nazarov reaction is an important endeavor in synthetic chemistry. Herein, we report enyne diketones, enables diastereo-...