Sensitivity and performance of three novel quantitative assays of SARS-CoV-2 nucleoprotein in blood

• Published in: Scientific reports Vol. 13; no. 1; p. 2868
• Main Authors: Hillig, Thore, Kristensen, Josephine R., Brasen, Claus L., Brandslund, Ivan, Olsen, Dorte A., Davidsen, Camilla, Madsen, Jonna S., Jensen, Claus A., Hansen, Young B. L., Friis-Hansen, Lennart
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.02.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/1807; 692/308; 692/420; 692/53; 692/700; Antigens; Biological Assay; Coronaviruses; COVID-19; COVID-19 - diagnosis; Enzyme-linked immunosorbent assay; Humanities and Social Sciences; Humans; Immunosorbents; multidisciplinary; N protein; Nucleoproteins; Plasma; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Viruses

To assess if SARS-CoV-2 (COVID-19) systemic disease can be determined by available nucleoprotein assays, we compared the performance of three commercial SARS-CoV-2 nucleoprotein (N) assays in plasma. A total of 272 plasma samples collected in the period November–December 2021 were analyzed by the me...