Enhance the delivery of light energy ultra-deep into turbid medium by controlling multiple scattering photons to travel in open channels
Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Ou...
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Published in | Light, science & applications Vol. 11; no. 1; pp. 108 - 10 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
24.04.2022
Springer Nature B.V Nature Publishing Group |
Subjects | |
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Abstract | Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Our method is based on a wide-field reflection matrix optical coherence tomography (RM-OCT). The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization parameter in order to get more accurate reversal results deep inside the scattering sample. We propose a concept named model energy matrix, which provides a direct mapping of light energy distribution inside the scattering sample. To the best of our knowledge, it is the first time that a method to measure and quantify the distribution of beam intensity inside a scattering sample is demonstrated. By employing the inversion of RM to find the matched wavefront and shaping with a phase-only spatial light modulator, we succeeded in both focusing a beam deep (~9.6 times of scattering mean free path, SMFP) inside the sample and increasing the delivery of light energy by an order of magnitude at an ultra-deep (~14.4 SMFP) position. This technique provides a powerful tool to understand the propagation of photon in a scattering medium and opens a new way to focus light inside biological tissues. |
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AbstractList | Abstract Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Our method is based on a wide-field reflection matrix optical coherence tomography (RM-OCT). The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization parameter in order to get more accurate reversal results deep inside the scattering sample. We propose a concept named model energy matrix, which provides a direct mapping of light energy distribution inside the scattering sample. To the best of our knowledge, it is the first time that a method to measure and quantify the distribution of beam intensity inside a scattering sample is demonstrated. By employing the inversion of RM to find the matched wavefront and shaping with a phase-only spatial light modulator, we succeeded in both focusing a beam deep (~9.6 times of scattering mean free path, SMFP) inside the sample and increasing the delivery of light energy by an order of magnitude at an ultra-deep (~14.4 SMFP) position. This technique provides a powerful tool to understand the propagation of photon in a scattering medium and opens a new way to focus light inside biological tissues. Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Our method is based on a wide-field reflection matrix optical coherence tomography (RM-OCT). The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization parameter in order to get more accurate reversal results deep inside the scattering sample. We propose a concept named model energy matrix, which provides a direct mapping of light energy distribution inside the scattering sample. To the best of our knowledge, it is the first time that a method to measure and quantify the distribution of beam intensity inside a scattering sample is demonstrated. By employing the inversion of RM to find the matched wavefront and shaping with a phase-only spatial light modulator, we succeeded in both focusing a beam deep (~9.6 times of scattering mean free path, SMFP) inside the sample and increasing the delivery of light energy by an order of magnitude at an ultra-deep (~14.4 SMFP) position. This technique provides a powerful tool to understand the propagation of photon in a scattering medium and opens a new way to focus light inside biological tissues. Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Our method is based on a wide-field reflection matrix optical coherence tomography (RM-OCT). The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization parameter in order to get more accurate reversal results deep inside the scattering sample. We propose a concept named model energy matrix, which provides a direct mapping of light energy distribution inside the scattering sample. To the best of our knowledge, it is the first time that a method to measure and quantify the distribution of beam intensity inside a scattering sample is demonstrated. By employing the inversion of RM to find the matched wavefront and shaping with a phase-only spatial light modulator, we succeeded in both focusing a beam deep (~9.6 times of scattering mean free path, SMFP) inside the sample and increasing the delivery of light energy by an order of magnitude at an ultra-deep (~14.4 SMFP) position. This technique provides a powerful tool to understand the propagation of photon in a scattering medium and opens a new way to focus light inside biological tissues.Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method to overcome this limitation and enhance the delivery of light energy ultra-deep into turbid media with significant improvement in focusing. Our method is based on a wide-field reflection matrix optical coherence tomography (RM-OCT). The time-reversal decomposition of the RM is calibrated with the Tikhonov regularization parameter in order to get more accurate reversal results deep inside the scattering sample. We propose a concept named model energy matrix, which provides a direct mapping of light energy distribution inside the scattering sample. To the best of our knowledge, it is the first time that a method to measure and quantify the distribution of beam intensity inside a scattering sample is demonstrated. By employing the inversion of RM to find the matched wavefront and shaping with a phase-only spatial light modulator, we succeeded in both focusing a beam deep (~9.6 times of scattering mean free path, SMFP) inside the sample and increasing the delivery of light energy by an order of magnitude at an ultra-deep (~14.4 SMFP) position. This technique provides a powerful tool to understand the propagation of photon in a scattering medium and opens a new way to focus light inside biological tissues. |
ArticleNumber | 108 |
Author | Miao, Yusi Qiu, Saijun Chen, Zhongping Cao, Jing Yang, Qiang Li, Yan Zhu, Zhikai Wang, Pinghe |
Author_xml | – sequence: 1 givenname: Jing surname: Cao fullname: Cao, Jing organization: Beckman Laser Institute, University of California, Irvine, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University – sequence: 2 givenname: Qiang surname: Yang fullname: Yang, Qiang organization: Beckman Laser Institute, University of California, Irvine – sequence: 3 givenname: Yusi surname: Miao fullname: Miao, Yusi organization: Beckman Laser Institute, University of California, Irvine, Department of Biomedical Engineering, University of California, Irvine – sequence: 4 givenname: Yan orcidid: 0000-0002-3468-9235 surname: Li fullname: Li, Yan organization: Beckman Laser Institute, University of California, Irvine, Department of Biomedical Engineering, University of California, Irvine – sequence: 5 givenname: Saijun surname: Qiu fullname: Qiu, Saijun organization: Beckman Laser Institute, University of California, Irvine, Department of Biomedical Engineering, University of California, Irvine – sequence: 6 givenname: Zhikai surname: Zhu fullname: Zhu, Zhikai organization: Beckman Laser Institute, University of California, Irvine, Department of Biomedical Engineering, University of California, Irvine – sequence: 7 givenname: Pinghe surname: Wang fullname: Wang, Pinghe email: wphsci@uestc.edu.cn organization: China State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China – sequence: 8 givenname: Zhongping surname: Chen fullname: Chen, Zhongping email: 2chen@uci.edu organization: Beckman Laser Institute, University of California, Irvine, Department of Biomedical Engineering, University of California, Irvine |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35462570$$D View this record in MEDLINE/PubMed |
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Snippet | Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative method... Abstract Multiple light scattering is considered as the major limitation for deep imaging and focusing in turbid media. In this paper, we present an innovative... |
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SubjectTerms | 639/624/1107/1110 639/624/1107/510 Applied and Technical Physics Atomic Classical and Continuum Physics Energy Lasers Light Light scattering Molecular Optical and Plasma Physics Optical Devices Optics Photonics Photons Physics Physics and Astronomy |
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Title | Enhance the delivery of light energy ultra-deep into turbid medium by controlling multiple scattering photons to travel in open channels |
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