Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

• Published in: Scientific reports Vol. 10; no. 1; p. 12217
• Main Authors: Kobayashi, Nobuyuki, Shinagawa, Shunichiro, Niimura, Hidehito, Kida, Hisashi, Nagata, Tomoyuki, Tagai, Kenji, Shimada, Kazuya, Oka, Naomi, Shikimoto, Ryo, Noda, Yoshihiro, Nakajima, Shinichiro, Mimura, Masaru, Shigeta, Masahiro, Kondo, Kazuhiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.07.2020; Nature Publishing Group
• Subjects: 631/208/176/1988; 692/308/53/2423; 692/699/375/132/1283; Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Apolipoproteins E - genetics; Area Under Curve; Base Sequence; Biomarkers - blood; Biometrics; Blood; Cardiovascular diseases; Cardiovascular Diseases - complications; Case-Control Studies; Coenzyme A; Cognitive ability; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - genetics; Cognitive Dysfunction - pathology; Dementia; Dementia disorders; Dementia, Vascular - complications; Deoxyribonucleic acid; Disease; DNA; DNA Methylation; Female; Genotype; Humanities and Social Sciences; Humans; Male; multidisciplinary; Neurodegeneration; Neurodegenerative diseases; Promoter Regions, Genetic; ROC Curve; Science; Science (multidisciplinary); Severity of Illness Index; Transferases - blood; Transferases - chemistry; Transferases - genetics; Vascular dementia

Early diagnosis of dementia including Alzheimer’s disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD...