Effect of linagliptin plus insulin in comparison to insulin alone on metabolic control and prognosis in hospitalized patients with SARS-CoV-2 infection

• Published in: Scientific reports Vol. 12; no. 1; pp. 536 - 12
• Main Authors: Guardado-Mendoza, Rodolfo, Garcia-Magaña, Miguel Angel, Martínez-Navarro, Liz Jovanna, Macías-Cervantes, Hilda Elizabeth, Aguilar-Guerrero, Rodolfo, Suárez-Pérez, Erick L., Aguilar-García, Alberto
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/596/4130; 692/163/2743/137/773; Blood Glucose - analysis; Clinical trials; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - diagnosis; COVID-19 - virology; Drug Therapy, Combination; Female; Glucose; Hospitalization; Humanities and Social Sciences; Humans; Hyperglycemia; Hyperglycemia - complications; Hyperglycemia - drug therapy; Hypoglycemia; Infections; Insulin; Insulin - therapeutic use; Length of Stay; Linagliptin - therapeutic use; Male; Mechanical ventilation; Metabolism; Middle Aged; multidisciplinary; NCT; NCT04542213; Patients; Prognosis; Proportional Hazards Models; Respiration, Artificial - statistics & numerical data; SARS-CoV-2 - isolation & purification; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Side effects; Ventilation

To evaluate the effect of the combination of linagliptin and insulin on metabolic control and prognosis in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia. A parallel double-blind randomized clinical trial including hospitalized pat...