FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion

• Published in: Nature communications Vol. 13; no. 1; pp. 3486 - 16
• Main Authors: Li, Shuaifeng, Han, Shixun, Zhang, Qi, Zhu, Yibing, Zhang, Haitao, Wang, Junli, Zhao, Yang, Zhao, Jianhui, Su, Lin, Li, Li, Zhou, Dawang, Ye, Cunqi, Feng, Xin-Hua, Liang, Tingbo, Zhao, Bin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.06.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 13/89; 13/95; 14; 14/19; 14/28; 38; 38/109; 631/67/1504/1610/4029; 631/67/2327; 631/80/642/333/1465; 64/60; Animals; Carcinogenesis - genetics; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Electron transport; Elongation; Fragmentation; GTP Phosphohydrolases - genetics; Hepatocellular carcinoma; Humanities and Social Sciences; Humans; Liver; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Membrane fusion; Mice; Mitochondria; Mitochondrial Dynamics; Mitochondrial Membrane Transport Proteins - genetics; Mitochondrial Membrane Transport Proteins - metabolism; Mitochondrial Proteins - metabolism; multidisciplinary; Science; Science (multidisciplinary); Therapeutic targets; Tumorigenesis

Mitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 ( FUNDC2 ) is transcriptionally upregulated...