Pharmacokinetics and Target Attainment of Antibiotics in Critically Ill Children: A Systematic Review of Current Literature

• Published in: Clinical pharmacokinetics Vol. 59; no. 2; pp. 173 - 205
• Main Authors: Hartman, Stan J. F., Brüggemann, Roger J., Orriëns, Lynn, Dia, Nada, Schreuder, Michiel F., de Wildt, Saskia N.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2020; Springer Nature B.V
• Subjects: Adults; Antibiotics; Drug dosages; Illnesses; Internal Medicine; Keywords; Medicine; Medicine & Public Health; Patients; Pediatrics; Penicillin; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Researchers; Studies; Subject heading schemes; Systematic Review

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target attainment of antibiotics in critically ill children. We aimed to identify gaps in current knowledge and to compare publi...