Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution

• Published in: Cell death & disease Vol. 12; no. 6; pp. 589 - 17
• Main Authors: Wang, Linhe, Li, Jie, He, Shuai, Liu, Yang, Chen, Haitian, He, Shujiao, Yin, Meixian, Zou, Dawei, Chen, Shirui, Luo, Tao, Yu, Xinyu, Wan, Xuesi, Huang, Shunwei, Guo, Zhiyong, He, Xiaoshun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.06.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 38/39; 38/47; 38/91; 631/80/304; 631/80/86; Adult; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Endothelial cells; Gene expression; Gene Expression Profiling - methods; Hepatocytes; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Immunology; Ischemia; Kupffer Cells - metabolism; Kupffer Cells - pathology; Life Sciences; Liver; Liver - blood supply; Liver - metabolism; Liver - pathology; Liver - physiopathology; Liver transplantation; Liver Transplantation - adverse effects; Liver transplants; Male; Middle Aged; Primary Graft Dysfunction - etiology; Primary Graft Dysfunction - genetics; Primary Graft Dysfunction - physiopathology; Reperfusion; Reperfusion Injury - genetics; Reperfusion Injury - physiopathology; RNA-Seq - methods; Single-Cell Analysis - methods; Transcription; Transcriptomes

Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transc...