Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution

Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transc...

Full description

Saved in:
Bibliographic Details
Published inCell death & disease Vol. 12; no. 6; pp. 589 - 17
Main Authors Wang, Linhe, Li, Jie, He, Shuai, Liu, Yang, Chen, Haitian, He, Shujiao, Yin, Meixian, Zou, Dawei, Chen, Shirui, Luo, Tao, Yu, Xinyu, Wan, Xuesi, Huang, Shunwei, Guo, Zhiyong, He, Xiaoshun
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.06.2021
Springer Nature B.V
Nature Publishing Group
Subjects
38/39
38/47
38/91
631/80/304
631/80/86
Adult
Antibodies
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Endothelial cells
Gene expression
Gene Expression Profiling - methods
Hepatocytes
Hepatocytes - metabolism
Hepatocytes - pathology
Humans
Immunology
Ischemia
Kupffer Cells - metabolism
Kupffer Cells - pathology
Life Sciences
Liver
Liver - blood supply
Liver - metabolism
Liver - pathology
Liver - physiopathology
Liver transplantation
Liver Transplantation - adverse effects
Liver transplants
Male
Middle Aged
Primary Graft Dysfunction - etiology
Primary Graft Dysfunction - genetics
Primary Graft Dysfunction - physiopathology
Reperfusion
Reperfusion Injury - genetics
Reperfusion Injury - physiopathology
RNA-Seq - methods
Single-Cell Analysis - methods
Transcription
Transcriptomes
Online AccessGet full text

Cover

Abstract Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transcriptional profile of intrahepatic cells during liver transplantation is still unclear. We performed a single-cell transcriptome analysis of 14,313 cells from liver tissues collected from pre-procurement, at the end of preservation and 2 h post-reperfusion. We made detailed annotations of mononuclear phagocyte, endothelial cell, NK/T, B and plasma cell clusters, and we described the dynamic changes of the transcriptome of these clusters during IRI and the interaction between mononuclear phagocyte clusters and other cell clusters. In addition, we found that TNFAIP3 interacting protein 3 ( TNIP3) , specifically and highly expressed in Kupffer cell clusters post-reperfusion, may have a protective effect on IRI. In summary, our study provides the first dynamic transcriptome map of intrahepatic cell clusters during liver transplantation at single-cell resolution.
AbstractList Abstract Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transcriptional profile of intrahepatic cells during liver transplantation is still unclear. We performed a single-cell transcriptome analysis of 14,313 cells from liver tissues collected from pre-procurement, at the end of preservation and 2 h post-reperfusion. We made detailed annotations of mononuclear phagocyte, endothelial cell, NK/T, B and plasma cell clusters, and we described the dynamic changes of the transcriptome of these clusters during IRI and the interaction between mononuclear phagocyte clusters and other cell clusters. In addition, we found that TNFAIP3 interacting protein 3 (TNIP3), specifically and highly expressed in Kupffer cell clusters post-reperfusion, may have a protective effect on IRI. In summary, our study provides the first dynamic transcriptome map of intrahepatic cell clusters during liver transplantation at single-cell resolution.
Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transcriptional profile of intrahepatic cells during liver transplantation is still unclear. We performed a single-cell transcriptome analysis of 14,313 cells from liver tissues collected from pre-procurement, at the end of preservation and 2 h post-reperfusion. We made detailed annotations of mononuclear phagocyte, endothelial cell, NK/T, B and plasma cell clusters, and we described the dynamic changes of the transcriptome of these clusters during IRI and the interaction between mononuclear phagocyte clusters and other cell clusters. In addition, we found that TNFAIP3 interacting protein 3 (TNIP3), specifically and highly expressed in Kupffer cell clusters post-reperfusion, may have a protective effect on IRI. In summary, our study provides the first dynamic transcriptome map of intrahepatic cell clusters during liver transplantation at single-cell resolution.
Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transcriptional profile of intrahepatic cells during liver transplantation is still unclear. We performed a single-cell transcriptome analysis of 14,313 cells from liver tissues collected from pre-procurement, at the end of preservation and 2 h post-reperfusion. We made detailed annotations of mononuclear phagocyte, endothelial cell, NK/T, B and plasma cell clusters, and we described the dynamic changes of the transcriptome of these clusters during IRI and the interaction between mononuclear phagocyte clusters and other cell clusters. In addition, we found that TNFAIP3 interacting protein 3 ( TNIP3) , specifically and highly expressed in Kupffer cell clusters post-reperfusion, may have a protective effect on IRI. In summary, our study provides the first dynamic transcriptome map of intrahepatic cell clusters during liver transplantation at single-cell resolution.
Ischemia-reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transcriptional profile of intrahepatic cells during liver transplantation is still unclear. We performed a single-cell transcriptome analysis of 14,313 cells from liver tissues collected from pre-procurement, at the end of preservation and 2 h post-reperfusion. We made detailed annotations of mononuclear phagocyte, endothelial cell, NK/T, B and plasma cell clusters, and we described the dynamic changes of the transcriptome of these clusters during IRI and the interaction between mononuclear phagocyte clusters and other cell clusters. In addition, we found that TNFAIP3 interacting protein 3 (TNIP3), specifically and highly expressed in Kupffer cell clusters post-reperfusion, may have a protective effect on IRI. In summary, our study provides the first dynamic transcriptome map of intrahepatic cell clusters during liver transplantation at single-cell resolution.Ischemia-reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes and numerous types of cells. However, a systematic and comprehensive single-cell transcriptional profile of intrahepatic cells during liver transplantation is still unclear. We performed a single-cell transcriptome analysis of 14,313 cells from liver tissues collected from pre-procurement, at the end of preservation and 2 h post-reperfusion. We made detailed annotations of mononuclear phagocyte, endothelial cell, NK/T, B and plasma cell clusters, and we described the dynamic changes of the transcriptome of these clusters during IRI and the interaction between mononuclear phagocyte clusters and other cell clusters. In addition, we found that TNFAIP3 interacting protein 3 (TNIP3), specifically and highly expressed in Kupffer cell clusters post-reperfusion, may have a protective effect on IRI. In summary, our study provides the first dynamic transcriptome map of intrahepatic cell clusters during liver transplantation at single-cell resolution.
ArticleNumber 589
Author Guo, Zhiyong
Huang, Shunwei
Yu, Xinyu
Chen, Shirui
Wan, Xuesi
He, Shujiao
Liu, Yang
Zou, Dawei
Wang, Linhe
Luo, Tao
He, Shuai
He, Xiaoshun
Li, Jie
Chen, Haitian
Yin, Meixian
Author_xml – sequence: 1
  givenname: Linhe
  orcidid: 0000-0001-7365-5209
  surname: Wang
  fullname: Wang, Linhe
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 2
  givenname: Jie
  surname: Li
  fullname: Li, Jie
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 3
  givenname: Shuai
  orcidid: 0000-0001-6619-1039
  surname: He
  fullname: He, Shuai
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine
– sequence: 4
  givenname: Yang
  surname: Liu
  fullname: Liu, Yang
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine
– sequence: 5
  givenname: Haitian
  surname: Chen
  fullname: Chen, Haitian
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine
– sequence: 6
  givenname: Shujiao
  surname: He
  fullname: He, Shujiao
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 7
  givenname: Meixian
  surname: Yin
  fullname: Yin, Meixian
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 8
  givenname: Dawei
  surname: Zou
  fullname: Zou, Dawei
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 9
  givenname: Shirui
  surname: Chen
  fullname: Chen, Shirui
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 10
  givenname: Tao
  surname: Luo
  fullname: Luo, Tao
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 11
  givenname: Xinyu
  surname: Yu
  fullname: Yu, Xinyu
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 12
  givenname: Xuesi
  surname: Wan
  fullname: Wan, Xuesi
  organization: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital, Sun Yat-Sen University
– sequence: 13
  givenname: Shunwei
  orcidid: 0000-0002-4655-9542
  surname: Huang
  fullname: Huang, Shunwei
  email: huangshunwei@163.com
  organization: Surgical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-Sen University
– sequence: 14
  givenname: Zhiyong
  orcidid: 0000-0002-5458-6268
  surname: Guo
  fullname: Guo, Zhiyong
  email: rockyucsf1981@126.com
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
– sequence: 15
  givenname: Xiaoshun
  orcidid: 0000-0001-9292-4283
  surname: He
  fullname: He, Xiaoshun
  email: gdtrc@163.com
  organization: Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34103479$$D View this record in MEDLINE/PubMed
BookMark eNp9kktr3DAURkVJadI0f6CLYuimG7d6WZY3hRL6CAQKpV0LWbqakfFIU8keyL-PPE7aJIt4I1s63-H66r5GJyEGQOgtwR8JZvJT5oSTrsaU1OWzlTV7gc4o5qTmUnYnD95P0UXOAy4PY5g24hU6Zbw4eNudoeEX5DgefNhU0xaqTdJuqnw2W9h5XSfYQ3Jz9jFUPgxzuqnsnBZ49AdI1ZR0yPtRh0lPC6OnoyUXYoTKwDhWafHPy-kb9NLpMcPF3XqO_nz7-vvyR3398_vV5Zfr2jQcT7WjWBPcE0xEbwTRXDhuDIO2aZueSSd7LCRuW2Zc14HFAgwmtoAtxuBaws7R1eq1UQ9qn_xOpxsVtVfHjZg2SqfJmxGUFL0WuAFpLeHWCo070fWGMkeN7Zkrrs-raz_3O7AGQvnl8ZH08UnwW7WJByWJbAXlRfDhTpDi3xnypHalu6UxOkCcs6IN6xoqWtkU9P0TdIhzCqVVCyWLT_CuUO8eVvSvlPsrLYBcAZNizgmcMn69nlKgHxXBahkgtQ6QKgOkjgOkWInSJ9F7-7MhtobyfpkMSP_LfiZ1C3UW2hE
CitedBy_id crossref_primary_10_1016_j_intimp_2024_111874
crossref_primary_10_2147_JIR_S468828
crossref_primary_10_3390_ijms24054636
crossref_primary_10_3390_bios14040189
crossref_primary_10_14348_molcells_2023_0099
crossref_primary_10_1097_TP_0000000000004365
crossref_primary_10_1111_jcmm_70336
crossref_primary_10_1055_a_2358_9505
crossref_primary_10_1111_cns_70154
crossref_primary_10_1007_s10047_024_01488_2
crossref_primary_10_1080_1744666X_2023_2240516
crossref_primary_10_3350_cmh_2024_0222
crossref_primary_10_1016_j_medj_2023_05_003
crossref_primary_10_1016_j_hbpd_2023_08_012
crossref_primary_10_1016_j_hbpd_2024_10_002
crossref_primary_10_1186_s43556_024_00185_z
crossref_primary_10_3390_cancers16162789
crossref_primary_10_1016_j_intimp_2024_113604
crossref_primary_10_1016_j_xinn_2024_100599
crossref_primary_10_1097_TP_0000000000004237
crossref_primary_10_1016_j_aohep_2024_101506
crossref_primary_10_1097_HEP_0000000000000346
crossref_primary_10_1038_s42003_023_04564_0
crossref_primary_10_1186_s10020_023_00653_2
crossref_primary_10_3390_ani14192873
crossref_primary_10_1002_iub_2804
crossref_primary_10_1016_j_isci_2023_108507
crossref_primary_10_1097_CM9_0000000000003527
crossref_primary_10_1038_s41467_023_37674_8
crossref_primary_10_1007_s12274_022_5071_2
crossref_primary_10_1097_SHK_0000000000002250
crossref_primary_10_3389_fimmu_2023_1096733
crossref_primary_10_1016_j_eng_2023_12_004
Cites_doi 10.1186/1742-2094-10-105
10.1517/14728220902794939
10.1016/j.cell.2017.05.035
10.1093/nar/gku1010
10.1038/s41467-019-09234-6
10.2119/2007-00134.Vardanian
10.1038/srep44356
10.1074/jbc.M607481200
10.1155/2018/3509091
10.1016/j.phrs.2018.06.022
10.1038/nbt.4096
10.1038/s41596-020-0292-x
10.1007/s002329900558
10.1016/j.jhep.2013.06.017
10.1161/JAHA.118.009384
10.3389/fimmu.2018.02235
10.1371/journal.pone.0077255
10.1093/nar/gkx1098
10.1186/1476-5926-1-1
10.1016/j.molimm.2019.09.010
10.1126/science.aat1699
10.1038/s41467-018-06318-7
10.4049/jimmunol.1101230
10.1002/hep.510280417
10.1038/s41586-019-1631-3
10.3748/wjg.v25.i47.6799
10.1093/nar/gky900
10.1038/s41421-020-0157-z
10.1016/j.immuni.2018.09.009
10.1002/lt.22117
10.1111/j.1538-7836.2005.01328.x
10.1679/aohc.65.251
10.1016/j.transproceed.2015.03.025
10.1111/j.1478-3231.2006.01342.x
10.1097/TP.0b013e3181e228db
10.1016/j.kint.2018.04.005
10.1182/blood-2002-10-3293
10.1161/CIRCULATIONAHA.117.030742
10.3748/wjg.v12.i34.5429
10.1002/jcb.26500
10.1093/bioinformatics/bts635
10.2217/epi-2018-0189
10.1016/S0016-5085(03)01048-5
10.1038/s41586-019-1373-2
10.1016/j.suc.2010.04.003
10.1038/360481a0
10.1038/s41586-018-0694-x
10.1016/S0021-9258(19)50477-X
10.1152/ajpgi.2000.279.1.G163
10.1021/acsnano.6b06245
10.1038/cti.2016.84
10.1002/hep.26419
10.1369/jhc.4A6514.2005
10.1016/j.molimm.2017.02.018
10.1186/s13045-018-0605-5
10.1038/ki.2014.403
10.3727/105221618X15216453076707
10.1179/1607845413Y.0000000079
10.4049/jimmunol.174.11.7341
10.1016/j.cmet.2020.03.007
10.1111/j.1745-7254.2006.00413.x
10.1016/j.bbrc.2019.09.111
10.7554/eLife.43882
ContentType Journal Article
Copyright The Author(s) 2021
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M2P
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.1038/s41419-021-03878-3
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni)
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database

CrossRef

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: Directory of Open Access Journals (DOAJ)
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central (New) (NC LIVE)
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-4889
EndPage 17
ExternalDocumentID oai_doaj_org_article_86ba605e8dd14dd6a0969bc23f2cdb3f
PMC8187624
34103479
10_1038_s41419_021_03878_3
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
3V.
53G
5VS
70F
7X7
88A
88I
8FE
8FH
8FI
8FJ
AAJSJ
ABUWG
ACGFS
ACSMW
ADBBV
AENEX
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
E3Z
EBLON
EBS
EMOBN
FRP
FYUFA
GNUQQ
GROUPED_DOAJ
HCIFZ
HMCUK
HYE
HZ~
KQ8
LK8
M0L
M2P
M48
M7P
M~E
NAO
O5R
O5S
O9-
OK1
PIMPY
PQQKQ
PROAC
RNT
RPM
SNYQT
TR2
UKHRP
W2D
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AARCD
K9.
PKEHL
PQEST
PQGLB
PQUKI
PRINS
Q9U
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c540t-f20a10b1016bc61a46f4cc3e7575b38f8b0680773cf99ed06ec01d61a700ef713
IEDL.DBID M48
ISSN 2041-4889
IngestDate Wed Aug 27 01:20:17 EDT 2025
Thu Aug 21 18:11:12 EDT 2025
Thu Jul 10 19:12:53 EDT 2025
Wed Aug 13 06:11:38 EDT 2025
Thu Apr 03 07:05:06 EDT 2025
Thu Apr 24 22:55:43 EDT 2025
Tue Jul 01 03:49:54 EDT 2025
Fri Feb 21 02:37:17 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-f20a10b1016bc61a46f4cc3e7575b38f8b0680773cf99ed06ec01d61a700ef713
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-4655-9542
0000-0002-5458-6268
0000-0001-7365-5209
0000-0001-6619-1039
0000-0001-9292-4283
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41419-021-03878-3
PMID 34103479
PQID 2538876649
PQPubID 2041963
PageCount 17
ParticipantIDs doaj_primary_oai_doaj_org_article_86ba605e8dd14dd6a0969bc23f2cdb3f
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8187624
proquest_miscellaneous_2539526785
proquest_journals_2538876649
pubmed_primary_34103479
crossref_citationtrail_10_1038_s41419_021_03878_3
crossref_primary_10_1038_s41419_021_03878_3
springer_journals_10_1038_s41419_021_03878_3
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-06-08
PublicationDateYYYYMMDD 2021-06-08
PublicationDate_xml – month: 06
  year: 2021
  text: 2021-06-08
  day: 08
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Cell death & disease
PublicationTitleAbbrev Cell Death Dis
PublicationTitleAlternate Cell Death Dis
PublicationYear 2021
Publisher Nature Publishing Group UK
Springer Nature B.V
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Springer Nature B.V
– name: Nature Publishing Group
References Liu (CR57) 2020; 31
Crinier (CR26) 2018; 49
Peralta (CR6) 2000; 279
Zerbino (CR17) 2018; 46
Cohen, Gutwein, Garach-Jehoshua, Bar-Haim, Kornberg (CR50) 2013; 18
Zhang (CR44) 2018; 564
Huang (CR42) 2019; 11
Bertola, Park, Gao (CR52) 2013; 58
Kobayashi (CR55) 2002; 65
Vardanian, Busuttil, Kupiec-Weglinski (CR53) 2008; 14
Zhou (CR63) 2015; 87
Braet, Wisse (CR31) 2002; 1
Fomin (CR13) 2013; 8
Wullaert (CR58) 2007; 282
Fraser, Dobbs, Rogers (CR32) 1995; 21
Pusztaszeri, Seelentag, Bosman (CR34) 2006; 54
Fawcett (CR38) 1992; 360
Travelli, Colombo, Mola, Genazzani, Porta (CR39) 2018; 135
Liu, Yan, Li, You, Gong (CR30) 2006; 27
Thorenz (CR43) 2018; 94
Zhang (CR21) 2019; 47
Crismale, Ahmad (CR1) 2019; 25
Lalor, Lai, Curbishley, Shetty, Adams (CR35) 2006; 12
Gladka (CR16) 2018; 138
Clark, Giltiay (CR48) 2018; 9
Paulino (CR2) 2015; 47
Cotrim-Sousa (CR47) 2019; 114
Zhou (CR22) 2019; 10
Berahovich (CR37) 2005; 174
Klune, Tsung (CR9) 2010; 90
Jourdan (CR27) 2011; 187
Ehrlich (CR24) 2018; 18
CR15
Young (CR28) 2018; 361
Li, He, Li, Liu, Gong (CR56) 2017; 85
Li (CR61) 2020; 521
Zheng (CR25) 2017; 169
Butler, Hoffman, Smibert, Papalexi, Satija (CR20) 2018; 36
Egashira (CR62) 2013; 10
Hajinejad (CR64) 2018; 119
Zwacka, Zhang, Zhou, Halldorson, Engelhardt (CR60) 1998; 28
Ramachandran (CR29) 2019; 575
Gracia-Sancho (CR4) 2010; 90
Chen, Zhao, Karnad, Freeman (CR40) 2018; 11
Katsargyris (CR8) 2009; 13
Efremova, Vento-Tormo, Teichmann, Vento-Tormo (CR23) 2020; 15
Cunningham (CR19) 2015; 43
Zhao (CR45) 2020; 6
Bilzer, Roggel, Gerbes (CR54) 2006; 26
Peralta, Jiménez-Castro, Gracia-Sancho (CR3) 2013; 59
Strauss, Phillips, Ruggiero, Bartlett, Dunbar (CR12) 2017; 7
Kamath, Furesz, Way, Smith (CR49) 1999; 171
MacParland (CR11) 2017; 11
Abu-Amara (CR51) 2010; 16
Aird (CR33) 2005; 3
Aizarani (CR36) 2019; 572
Soppert (CR41) 2018; 7
Sherif, Al-Shaalan (CR59) 2018; 2018
Selzner, Rudiger, Graf, Clavien (CR5) 2003; 125
Dobin (CR18) 2013; 29
Beider (CR46) 2003; 102
MacParland (CR14) 2018; 9
Gasbarrini (CR7) 1992; 267
McNamara, Cockburn (CR10) 2016; 5
D Liu (3878_CR57) 2020; 31
DR Zerbino (3878_CR17) 2018; 46
A Thorenz (3878_CR43) 2018; 94
Y Zhou (3878_CR22) 2019; 10
A Katsargyris (3878_CR8) 2009; 13
M Jourdan (3878_CR27) 2011; 187
SG Kamath (3878_CR49) 1999; 171
Y Cohen (3878_CR50) 2013; 18
T Kobayashi (3878_CR55) 2002; 65
MD Young (3878_CR28) 2018; 361
Y Egashira (3878_CR62) 2013; 10
C Chen (3878_CR40) 2018; 11
SA MacParland (3878_CR14) 2018; 9
AJ Vardanian (3878_CR53) 2008; 14
X Li (3878_CR61) 2020; 521
S Huang (3878_CR42) 2019; 11
A Gasbarrini (3878_CR7) 1992; 267
J Soppert (3878_CR41) 2018; 7
A Wullaert (3878_CR58) 2007; 282
N Selzner (3878_CR5) 2003; 125
PF Lalor (3878_CR35) 2006; 12
M Abu-Amara (3878_CR51) 2010; 16
3878_CR15
RD Berahovich (3878_CR37) 2005; 174
A Butler (3878_CR20) 2018; 36
O Strauss (3878_CR12) 2017; 7
SA MacParland (3878_CR11) 2017; 11
R Fraser (3878_CR32) 1995; 21
J Fawcett (3878_CR38) 1992; 360
L Ehrlich (3878_CR24) 2018; 18
J Gracia-Sancho (3878_CR4) 2010; 90
M Bilzer (3878_CR54) 2006; 26
JF Crismale (3878_CR1) 2019; 25
JR Klune (3878_CR9) 2010; 90
K Beider (3878_CR46) 2003; 102
IO Sherif (3878_CR59) 2018; 2018
A Dobin (3878_CR18) 2013; 29
HA McNamara (3878_CR10) 2016; 5
A Bertola (3878_CR52) 2013; 58
F Cunningham (3878_CR19) 2015; 43
ME Fomin (3878_CR13) 2013; 8
P Ramachandran (3878_CR29) 2019; 575
L Cotrim-Sousa (3878_CR47) 2019; 114
L Zhang (3878_CR44) 2018; 564
C Travelli (3878_CR39) 2018; 135
N Aizarani (3878_CR36) 2019; 572
X Zhang (3878_CR21) 2019; 47
EA Clark (3878_CR48) 2018; 9
J Zhao (3878_CR45) 2020; 6
ZJ Liu (3878_CR30) 2006; 27
P Li (3878_CR56) 2017; 85
M Efremova (3878_CR23) 2020; 15
F Braet (3878_CR31) 2002; 1
RM Zwacka (3878_CR60) 1998; 28
C Peralta (3878_CR3) 2013; 59
J Paulino (3878_CR2) 2015; 47
MM Gladka (3878_CR16) 2018; 138
WC Aird (3878_CR33) 2005; 3
M Zhou (3878_CR63) 2015; 87
M Hajinejad (3878_CR64) 2018; 119
MP Pusztaszeri (3878_CR34) 2006; 54
C Peralta (3878_CR6) 2000; 279
C Zheng (3878_CR25) 2017; 169
A Crinier (3878_CR26) 2018; 49
References_xml – volume: 10
  year: 2013
  ident: CR62
  article-title: The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment
  publication-title: J. Neuroinflamm.
  doi: 10.1186/1742-2094-10-105
– volume: 13
  start-page: 427
  year: 2009
  end-page: 42
  ident: CR8
  article-title: Toll-like receptors in liver ischemia reperfusion injury: a novel target for therapeutic modulation?
  publication-title: Expert Opin. Therap. Targets
  doi: 10.1517/14728220902794939
– volume: 169
  start-page: 1342
  year: 2017
  end-page: 56.e16
  ident: CR25
  article-title: Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing
  publication-title: Cell
  doi: 10.1016/j.cell.2017.05.035
– volume: 43
  start-page: D662
  year: 2015
  end-page: 9
  ident: CR19
  article-title: Ensembl 2015
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1010
– volume: 10
  year: 2019
  ident: CR22
  article-title: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09234-6
– volume: 14
  start-page: 337
  year: 2008
  end-page: 45
  ident: CR53
  article-title: Molecular mediators of liver ischemia and reperfusion injury: a brief review
  publication-title: Mol. Med.
  doi: 10.2119/2007-00134.Vardanian
– volume: 7
  year: 2017
  ident: CR12
  article-title: Immunofluorescence identifies distinct subsets of endothelial cells in the human liver
  publication-title: Sci. Rep.
  doi: 10.1038/srep44356
– volume: 282
  start-page: 81
  year: 2007
  end-page: 90
  ident: CR58
  article-title: LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M607481200
– volume: 2018
  start-page: 3509091
  year: 2018
  ident: CR59
  article-title: Vildagliptin attenuates hepatic ischemia/reperfusion injury via the TLR4/NF-κB signaling pathway
  publication-title: Oxid. Med Cell Longev.
  doi: 10.1155/2018/3509091
– volume: 21
  start-page: 863
  year: 1995
  end-page: 74
  ident: CR32
  article-title: Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis
  publication-title: Hepatology
– volume: 135
  start-page: 25
  year: 2018
  end-page: 36
  ident: CR39
  article-title: NAMPT: a pleiotropic modulator of monocytes and macrophages
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2018.06.022
– volume: 36
  start-page: 411
  year: 2018
  end-page: 20
  ident: CR20
  article-title: Integrating single-cell transcriptomic data across different conditions, technologies, and species
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 15
  start-page: 1484
  year: 2020
  end-page: 506
  ident: CR23
  article-title: CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-020-0292-x
– volume: 171
  start-page: 55
  year: 1999
  end-page: 62
  ident: CR49
  article-title: Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1. The
  publication-title: J. Membr. Biol.
  doi: 10.1007/s002329900558
– volume: 59
  start-page: 1094
  year: 2013
  end-page: 106
  ident: CR3
  article-title: Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2013.06.017
– volume: 7
  start-page: e009384
  year: 2018
  ident: CR41
  article-title: Soluble CD74 reroutes MIF/CXCR4/AKT-mediated survival of cardiac myofibroblasts to necroptosis
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.118.009384
– volume: 9
  start-page: 2235
  year: 2018
  ident: CR48
  article-title: CD22: a regulator of innate and adaptive B cell responses and autoimmunity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02235
– volume: 8
  start-page: e77255
  year: 2013
  ident: CR13
  article-title: Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0077255
– volume: 46
  start-page: D754
  year: 2018
  end-page: d61
  ident: CR17
  article-title: Ensembl 2018
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1098
– volume: 1
  year: 2002
  ident: CR31
  article-title: Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review
  publication-title: Comp. Hepatol.
  doi: 10.1186/1476-5926-1-1
– volume: 114
  start-page: 600
  year: 2019
  end-page: 11
  ident: CR47
  article-title: Adhesion between medullary thymic epithelial cells and thymocytes is regulated by miR-181b-5p and miR-30b
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2019.09.010
– ident: CR15
– volume: 361
  start-page: 594
  year: 2018
  end-page: 9
  ident: CR28
  article-title: Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
  publication-title: Science
  doi: 10.1126/science.aat1699
– volume: 9
  year: 2018
  ident: CR14
  article-title: Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06318-7
– volume: 187
  start-page: 3931
  year: 2011
  end-page: 41
  ident: CR27
  article-title: Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1101230
– volume: 28
  start-page: 1022
  year: 1998
  end-page: 30
  ident: CR60
  article-title: Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation
  publication-title: Hepatology
  doi: 10.1002/hep.510280417
– volume: 575
  start-page: 512
  year: 2019
  end-page: 8
  ident: CR29
  article-title: Resolving the fibrotic niche of human liver cirrhosis at single-cell level
  publication-title: Nature
  doi: 10.1038/s41586-019-1631-3
– volume: 25
  start-page: 6799
  year: 2019
  end-page: 812
  ident: CR1
  article-title: Expanding the donor pool: hepatitis C, hepatitis B and human immunodeficiency virus-positive donors in liver transplantation
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v25.i47.6799
– volume: 47
  start-page: D721
  year: 2019
  end-page: d8
  ident: CR21
  article-title: CellMarker: a manually curated resource of cell markers in human and mouse
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky900
– volume: 6
  start-page: 22
  year: 2020
  ident: CR45
  article-title: Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human
  publication-title: Cell Discov.
  doi: 10.1038/s41421-020-0157-z
– volume: 49
  start-page: 971
  year: 2018
  end-page: 86.e5
  ident: CR26
  article-title: High-dimensional single-cell analysis identifies organ-specific signatures and conserved NK cell subsets in humans and mice
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.09.009
– volume: 16
  start-page: 1016
  year: 2010
  end-page: 32
  ident: CR51
  article-title: Liver ischemia/reperfusion injury: processes in inflammatory networks—a review
  publication-title: Liver Transpl.
  doi: 10.1002/lt.22117
– volume: 3
  start-page: 1392
  year: 2005
  end-page: 406
  ident: CR33
  article-title: Spatial and temporal dynamics of the endothelium
  publication-title: J. thrombosis Haemost.: Jth.
  doi: 10.1111/j.1538-7836.2005.01328.x
– volume: 65
  start-page: 251
  year: 2002
  end-page: 61
  ident: CR55
  article-title: The protective role of Kupffer cells in the ischemia-reperfused rat liver
  publication-title: Arch. Histol. Cytol.
  doi: 10.1679/aohc.65.251
– volume: 47
  start-page: 882
  year: 2015
  end-page: 7
  ident: CR2
  article-title: Clinical outcomes and genetic expression profile in human liver graft dysfunction during ischemia/reperfusion injury
  publication-title: Transpl. Proc.
  doi: 10.1016/j.transproceed.2015.03.025
– volume: 26
  start-page: 1175
  year: 2006
  end-page: 86
  ident: CR54
  article-title: Role of Kupffer cells in host defense and liver disease
  publication-title: Liver Int.
  doi: 10.1111/j.1478-3231.2006.01342.x
– volume: 90
  start-page: 142
  year: 2010
  end-page: 9
  ident: CR4
  article-title: Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e3181e228db
– volume: 94
  start-page: 741
  year: 2018
  end-page: 55
  ident: CR43
  article-title: Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury-induced inflammation and fibrosis
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2018.04.005
– volume: 102
  start-page: 1951
  year: 2003
  end-page: 8
  ident: CR46
  article-title: Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice
  publication-title: Blood
  doi: 10.1182/blood-2002-10-3293
– volume: 138
  start-page: 166
  year: 2018
  end-page: 80
  ident: CR16
  article-title: Single-cell sequencing of the healthy and diseased heart reveals cytoskeleton-associated protein 4 as a new modulator of fibroblasts activation
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.117.030742
– volume: 12
  start-page: 5429
  year: 2006
  end-page: 39
  ident: CR35
  article-title: Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v12.i34.5429
– volume: 119
  start-page: 2939
  year: 2018
  end-page: 50
  ident: CR64
  article-title: Resveratrol pretreatment enhanced homing of SDF-1α-preconditioned bone marrow-derived mesenchymal stem cells in a rat model of liver cirrhosis
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.26500
– volume: 29
  start-page: 15
  year: 2013
  end-page: 21
  ident: CR18
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
– volume: 11
  start-page: 527
  year: 2019
  end-page: 42
  ident: CR42
  article-title: Comprehensive and combined omics analysis reveals factors of ischemia-reperfusion injury in liver transplantation
  publication-title: Epigenomics
  doi: 10.2217/epi-2018-0189
– volume: 125
  start-page: 917
  year: 2003
  end-page: 36
  ident: CR5
  article-title: Protective strategies against ischemic injury of the liver
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(03)01048-5
– volume: 572
  start-page: 199
  year: 2019
  end-page: 204
  ident: CR36
  article-title: A human liver cell atlas reveals heterogeneity and epithelial progenitors
  publication-title: Nature
  doi: 10.1038/s41586-019-1373-2
– volume: 90
  start-page: 665
  year: 2010
  end-page: 77
  ident: CR9
  article-title: Molecular biology of liver ischemia/reperfusion injury: established mechanisms and recent advancements
  publication-title: Surg. Clin. North Am.
  doi: 10.1016/j.suc.2010.04.003
– volume: 360
  start-page: 481
  year: 1992
  end-page: 4
  ident: CR38
  article-title: Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes
  publication-title: Nature
  doi: 10.1038/360481a0
– volume: 564
  start-page: 268
  year: 2018
  end-page: 72
  ident: CR44
  article-title: Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
  publication-title: Nature
  doi: 10.1038/s41586-018-0694-x
– volume: 267
  start-page: 6654
  year: 1992
  end-page: 63
  ident: CR7
  article-title: Effect of anoxia on intracellular ATP, Na+i, Ca2+i, Mg2+i, and cytotoxicity in rat hepatocytes
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)50477-X
– volume: 279
  start-page: G163
  year: 2000
  end-page: 71
  ident: CR6
  article-title: Hepatic preconditioning preserves energy metabolism during sustained ischemia
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.2000.279.1.G163
– volume: 11
  start-page: 2428
  year: 2017
  end-page: 43
  ident: CR11
  article-title: Phenotype determines nanoparticle uptake by human macrophages from liver and blood
  publication-title: ACS Nano
  doi: 10.1021/acsnano.6b06245
– volume: 5
  start-page: e123
  year: 2016
  ident: CR10
  article-title: The three Rs: recruitment, retention and residence of leukocytes in the liver
  publication-title: Clin. Transl. Immunol.
  doi: 10.1038/cti.2016.84
– volume: 58
  start-page: 1814
  year: 2013
  end-page: 23
  ident: CR52
  article-title: Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin
  publication-title: Hepatology
  doi: 10.1002/hep.26419
– volume: 54
  start-page: 385
  year: 2006
  end-page: 95
  ident: CR34
  article-title: Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues
  publication-title: J. Histochem. Cytochem.
  doi: 10.1369/jhc.4A6514.2005
– volume: 85
  start-page: 222
  year: 2017
  end-page: 9
  ident: CR56
  article-title: The role of Kupffer cells in hepatic diseases
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2017.02.018
– volume: 11
  start-page: 64
  year: 2018
  ident: CR40
  article-title: The biology and role of CD44 in cancer progression: therapeutic implications
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-018-0605-5
– volume: 87
  start-page: 918
  year: 2015
  end-page: 29
  ident: CR63
  article-title: Progranulin protects against renal ischemia/reperfusion injury in mice
  publication-title: Kidney Int.
  doi: 10.1038/ki.2014.403
– volume: 18
  start-page: 197
  year: 2018
  end-page: 207
  ident: CR24
  article-title: α7-nAChR knockout mice decreases biliary hyperplasia and liver fibrosis in cholestatic bile duct-ligated mice
  publication-title: Gene Expr.
  doi: 10.3727/105221618X15216453076707
– volume: 18
  start-page: 348
  year: 2013
  end-page: 51
  ident: CR50
  article-title: GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells
  publication-title: Hematology
  doi: 10.1179/1607845413Y.0000000079
– volume: 174
  start-page: 7341
  year: 2005
  end-page: 51
  ident: CR37
  article-title: Proteolytic activation of alternative CCR1 ligands in inflammation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.11.7341
– volume: 31
  start-page: 726
  year: 2020
  end-page: 40.e8
  ident: CR57
  article-title: TNFAIP3 interacting protein 3 overexpression suppresses nonalcoholic steatohepatitis by blocking TAK1 activation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2020.03.007
– volume: 27
  start-page: 1479
  year: 2006
  end-page: 86
  ident: CR30
  article-title: Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1111/j.1745-7254.2006.00413.x
– volume: 521
  start-page: 569
  year: 2020
  end-page: 76
  ident: CR61
  article-title: Progranulin protects against cerebral ischemia-reperfusion (I/R) injury by inhibiting necroptosis and oxidative stress
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2019.09.111
– volume: 18
  start-page: 197
  year: 2018
  ident: 3878_CR24
  publication-title: Gene Expr.
  doi: 10.3727/105221618X15216453076707
– volume: 564
  start-page: 268
  year: 2018
  ident: 3878_CR44
  publication-title: Nature
  doi: 10.1038/s41586-018-0694-x
– volume: 43
  start-page: D662
  year: 2015
  ident: 3878_CR19
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1010
– volume: 187
  start-page: 3931
  year: 2011
  ident: 3878_CR27
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1101230
– volume: 47
  start-page: 882
  year: 2015
  ident: 3878_CR2
  publication-title: Transpl. Proc.
  doi: 10.1016/j.transproceed.2015.03.025
– volume: 59
  start-page: 1094
  year: 2013
  ident: 3878_CR3
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2013.06.017
– volume: 29
  start-page: 15
  year: 2013
  ident: 3878_CR18
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
– ident: 3878_CR15
  doi: 10.7554/eLife.43882
– volume: 36
  start-page: 411
  year: 2018
  ident: 3878_CR20
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 31
  start-page: 726
  year: 2020
  ident: 3878_CR57
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2020.03.007
– volume: 361
  start-page: 594
  year: 2018
  ident: 3878_CR28
  publication-title: Science
  doi: 10.1126/science.aat1699
– volume: 114
  start-page: 600
  year: 2019
  ident: 3878_CR47
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2019.09.010
– volume: 135
  start-page: 25
  year: 2018
  ident: 3878_CR39
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2018.06.022
– volume: 102
  start-page: 1951
  year: 2003
  ident: 3878_CR46
  publication-title: Blood
  doi: 10.1182/blood-2002-10-3293
– volume: 12
  start-page: 5429
  year: 2006
  ident: 3878_CR35
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v12.i34.5429
– volume: 10
  year: 2013
  ident: 3878_CR62
  publication-title: J. Neuroinflamm.
  doi: 10.1186/1742-2094-10-105
– volume: 11
  start-page: 527
  year: 2019
  ident: 3878_CR42
  publication-title: Epigenomics
  doi: 10.2217/epi-2018-0189
– volume: 282
  start-page: 81
  year: 2007
  ident: 3878_CR58
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M607481200
– volume: 94
  start-page: 741
  year: 2018
  ident: 3878_CR43
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2018.04.005
– volume: 16
  start-page: 1016
  year: 2010
  ident: 3878_CR51
  publication-title: Liver Transpl.
  doi: 10.1002/lt.22117
– volume: 521
  start-page: 569
  year: 2020
  ident: 3878_CR61
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2019.09.111
– volume: 9
  start-page: 2235
  year: 2018
  ident: 3878_CR48
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02235
– volume: 47
  start-page: D721
  year: 2019
  ident: 3878_CR21
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky900
– volume: 572
  start-page: 199
  year: 2019
  ident: 3878_CR36
  publication-title: Nature
  doi: 10.1038/s41586-019-1373-2
– volume: 267
  start-page: 6654
  year: 1992
  ident: 3878_CR7
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)50477-X
– volume: 9
  year: 2018
  ident: 3878_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06318-7
– volume: 26
  start-page: 1175
  year: 2006
  ident: 3878_CR54
  publication-title: Liver Int.
  doi: 10.1111/j.1478-3231.2006.01342.x
– volume: 21
  start-page: 863
  year: 1995
  ident: 3878_CR32
  publication-title: Hepatology
– volume: 46
  start-page: D754
  year: 2018
  ident: 3878_CR17
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1098
– volume: 65
  start-page: 251
  year: 2002
  ident: 3878_CR55
  publication-title: Arch. Histol. Cytol.
  doi: 10.1679/aohc.65.251
– volume: 18
  start-page: 348
  year: 2013
  ident: 3878_CR50
  publication-title: Hematology
  doi: 10.1179/1607845413Y.0000000079
– volume: 13
  start-page: 427
  year: 2009
  ident: 3878_CR8
  publication-title: Expert Opin. Therap. Targets
  doi: 10.1517/14728220902794939
– volume: 28
  start-page: 1022
  year: 1998
  ident: 3878_CR60
  publication-title: Hepatology
  doi: 10.1002/hep.510280417
– volume: 125
  start-page: 917
  year: 2003
  ident: 3878_CR5
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(03)01048-5
– volume: 15
  start-page: 1484
  year: 2020
  ident: 3878_CR23
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-020-0292-x
– volume: 7
  start-page: e009384
  year: 2018
  ident: 3878_CR41
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.118.009384
– volume: 360
  start-page: 481
  year: 1992
  ident: 3878_CR38
  publication-title: Nature
  doi: 10.1038/360481a0
– volume: 54
  start-page: 385
  year: 2006
  ident: 3878_CR34
  publication-title: J. Histochem. Cytochem.
  doi: 10.1369/jhc.4A6514.2005
– volume: 138
  start-page: 166
  year: 2018
  ident: 3878_CR16
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.117.030742
– volume: 169
  start-page: 1342
  year: 2017
  ident: 3878_CR25
  publication-title: Cell
  doi: 10.1016/j.cell.2017.05.035
– volume: 279
  start-page: G163
  year: 2000
  ident: 3878_CR6
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.2000.279.1.G163
– volume: 5
  start-page: e123
  year: 2016
  ident: 3878_CR10
  publication-title: Clin. Transl. Immunol.
  doi: 10.1038/cti.2016.84
– volume: 575
  start-page: 512
  year: 2019
  ident: 3878_CR29
  publication-title: Nature
  doi: 10.1038/s41586-019-1631-3
– volume: 3
  start-page: 1392
  year: 2005
  ident: 3878_CR33
  publication-title: J. thrombosis Haemost.: Jth.
  doi: 10.1111/j.1538-7836.2005.01328.x
– volume: 171
  start-page: 55
  year: 1999
  ident: 3878_CR49
  publication-title: J. Membr. Biol.
  doi: 10.1007/s002329900558
– volume: 2018
  start-page: 3509091
  year: 2018
  ident: 3878_CR59
  publication-title: Oxid. Med Cell Longev.
  doi: 10.1155/2018/3509091
– volume: 1
  year: 2002
  ident: 3878_CR31
  publication-title: Comp. Hepatol.
  doi: 10.1186/1476-5926-1-1
– volume: 49
  start-page: 971
  year: 2018
  ident: 3878_CR26
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.09.009
– volume: 85
  start-page: 222
  year: 2017
  ident: 3878_CR56
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2017.02.018
– volume: 7
  year: 2017
  ident: 3878_CR12
  publication-title: Sci. Rep.
  doi: 10.1038/srep44356
– volume: 119
  start-page: 2939
  year: 2018
  ident: 3878_CR64
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.26500
– volume: 25
  start-page: 6799
  year: 2019
  ident: 3878_CR1
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v25.i47.6799
– volume: 27
  start-page: 1479
  year: 2006
  ident: 3878_CR30
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1111/j.1745-7254.2006.00413.x
– volume: 87
  start-page: 918
  year: 2015
  ident: 3878_CR63
  publication-title: Kidney Int.
  doi: 10.1038/ki.2014.403
– volume: 8
  start-page: e77255
  year: 2013
  ident: 3878_CR13
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0077255
– volume: 11
  start-page: 2428
  year: 2017
  ident: 3878_CR11
  publication-title: ACS Nano
  doi: 10.1021/acsnano.6b06245
– volume: 6
  start-page: 22
  year: 2020
  ident: 3878_CR45
  publication-title: Cell Discov.
  doi: 10.1038/s41421-020-0157-z
– volume: 90
  start-page: 142
  year: 2010
  ident: 3878_CR4
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e3181e228db
– volume: 14
  start-page: 337
  year: 2008
  ident: 3878_CR53
  publication-title: Mol. Med.
  doi: 10.2119/2007-00134.Vardanian
– volume: 10
  year: 2019
  ident: 3878_CR22
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09234-6
– volume: 174
  start-page: 7341
  year: 2005
  ident: 3878_CR37
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.11.7341
– volume: 90
  start-page: 665
  year: 2010
  ident: 3878_CR9
  publication-title: Surg. Clin. North Am.
  doi: 10.1016/j.suc.2010.04.003
– volume: 11
  start-page: 64
  year: 2018
  ident: 3878_CR40
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-018-0605-5
– volume: 58
  start-page: 1814
  year: 2013
  ident: 3878_CR52
  publication-title: Hepatology
  doi: 10.1002/hep.26419
SSID ssj0000330256
Score 2.477366
Snippet Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism...
Ischemia-reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism...
Abstract Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 589
SubjectTerms 38/39
38/47
38/91
631/80/304
631/80/86
Adult
Antibodies
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Endothelial cells
Gene expression
Gene Expression Profiling - methods
Hepatocytes
Hepatocytes - metabolism
Hepatocytes - pathology
Humans
Immunology
Ischemia
Kupffer Cells - metabolism
Kupffer Cells - pathology
Life Sciences
Liver
Liver - blood supply
Liver - metabolism
Liver - pathology
Liver - physiopathology
Liver transplantation
Liver Transplantation - adverse effects
Liver transplants
Male
Middle Aged
Primary Graft Dysfunction - etiology
Primary Graft Dysfunction - genetics
Primary Graft Dysfunction - physiopathology
Reperfusion
Reperfusion Injury - genetics
Reperfusion Injury - physiopathology
RNA-Seq - methods
Single-Cell Analysis - methods
Transcription
Transcriptomes
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuiPJMW5CRuEFUJ3Ec-wiIqkKCE5V6s_wYw1YhrdLsgX_PjJNdujwvXBMnssYz-b6ZzIOxFy20CCIyljX6E6VUdSi9NGhXACZULgXjqN75w0d1eibfn7fnN0Z9UU7Y3B54FtyxVt4h5QYdYyVjVA45t_GhblIdom8SfX0R8244U_kbjG46gvlSJSMafXwtK0n1OjVlEGnKCdhBotyw_3cs89dkyZ_-mGYgOrnH7i4Mkr-ed77PbsFwn92eZ0p-e8AuKCDfU5iAI7fjn0eXJr5CHxa-rlw5whWMaU0hMr4aLlCgfC5U5D0laPAp9zrv3VyQNHA35bdQQKEHTlF-PsJGXR-ys5N3n96elstAhTIgMZvKVAtXCU8Ouw-qclIlGUIDHXI23-ikPU3i6LomJGMgCgVBVBEXdkJAQnf2EdsbLgd4wrgwqUPkNxKMkVWqNJEJiCb4NqjYdQWrNsK1Yek2TkMvepv_ejfazgdi8UBsPhDbFOzl9pmrudfGX1e_oTPbrqQ-2fkCao9dtMf-S3sKdrQ5cbsY77WtEQQQJJQ0BXu-vY1mR1J2A1yu8xrT1oj0bcEezwqy3QkSA0EFugXrdlRnZ6u7d4bVl9zaG-kTopMs2KuNkv3Y1p9FcfA_RHHI7tTZOlQp9BHbm8Y1PEXCNfln2ba-AxGTKI0
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k2gICNxg6hO4tjxCQGiqpDgRKW9WX6WrUJ2yWYP_HtmnEe1PHqNncjxzHi-Gc-DkNd1qEGJcJ-XYE_kXJQut1yBXIWgXGGiUwbznb98FWfn_POqXk0Ot90UVjmfiemg9huHPvKTEiQTJFdw9W77M8euUXi7OrXQuEluYeky5Gq5kouPhYGxDip9ypVhVXOy4wXHrJ0S44gajAw40EepbP-_sObfIZN_3JsmdXR6j9ydcCR9PxL-PrkRugfk9thZ8tdDcolu-RadBRQQHr3oTRzoGizZ8GNt8j5sQx_36Cij6-4StpWO6Yq0xTANOqSK560Z05I6aob0FXQrtIGir5_2YWbaR-T89NO3j2f51FYhdwDPhjyWzBTMotlunSgMF5E7VwUJyM1WTWws9uOQsnJRqeCZCI4VHiZKxkIEo_YxOeo2XXhKKFNRgv5XPCjFi1g0CCmCV87WTngpM1LMm6vdVHMcW1-0Ot19V40eCaKBIDoRRFcZebO8sx0rblw7-wPSbJmJ1bLTg01_oSfh042wBsy20HhfcO-FAbtNWVdWsXTeVjEjxzPF9STCO33FcBl5tQyD8OEumy5s9mmOqkvQ93VGnowMsqwE4AHDNN2MyAPWOVjq4Ui3_p4KfAOIAh3FM_J2ZrKrZf1_K55d_xfPyZ0y8b3IWXNMjoZ-H14AoBrsyyQ1vwEzHx77
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VVkhcEG8CBRmJG0Q4juPExwVRVSvBBSr1ZvlZtgrZKs0e-PeMnQdaKEhcN5OV5ZnJ9814ZgzwuvIVggh3OcN4IueC2dxwiX7lvbSFDlbq2O_86bM4PePr8-r8ANjcC5OK9tNIy_SZnqvD3l3zgsd2GxYLgJp4pH8LjuKodrTto9Vq_WW9ZFYohugI5FOHDErf8PIeCqVh_TcxzD8LJX87LU0gdHIP7k7skazG9d6HA989gNvjfZI_HsJlTMa3MUVAkNeRi16HgWwwfvXfNzrv_ZXvwy6mx8imu8TNJGOTImljcQYZ0pzzVo_NSB3RQ_qXmExoPYkZftL72VQfwdnJx68fTvPpMoXcIikb8sCoLqiJwbqxotBcBG5t6Wvka6ZsQmPiLRx1XdogpXdUeEsLh4I1pT5gKPsYDrtt558CoTLUiPqSeyl5EYomEgnvpDWVFa6uMyjmzVV2mjQeL7xoVTrxLhs1KkShQlRSiCozeLO8czXO2fin9Puos0UyzshOP2z7CzXZjGqE0Ris-ca5gjsnNEZr0lhWBmadKUMGx7PG1eS414ohACBACC4zeLU8RpeLu6w7v90lGVkxRPkqgyejgSwrQVJAY3NuBvWe6ewtdf9Jt_mWxnojdUJk4hm8nY3s17L-vhXP_k_8OdxhyQ9ETptjOBz6nX-BtGowLyc_-gnv4R38
  priority: 102
  providerName: Springer Nature
Title Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution
URI https://link.springer.com/article/10.1038/s41419-021-03878-3
https://www.ncbi.nlm.nih.gov/pubmed/34103479
https://www.proquest.com/docview/2538876649
https://www.proquest.com/docview/2539526785
https://pubmed.ncbi.nlm.nih.gov/PMC8187624
https://doaj.org/article/86ba605e8dd14dd6a0969bc23f2cdb3f
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3di9NAEB_uA8EX8dvoWVbwTaP52OxmH0R6pcdRuEPUQt_CZj_OHjE9cyl4L_7tzm6SSrUKvrSQTMpmPjq_md2ZAXiZmQydCNVhgvFESFmiwpIKtCtjhIqlVUK6euezc3Y6p7NFttiDYdxRz8DrnaGdmyc1b6o337_dvEeDf9eVjOdvr2lMXSlO4g4H5W67fx8O0TNxN9HgrIf7_p8Zg3d08X3tzO5Ht_yTb-O_C3v-eYTyt31U755O7sKdHleScacI92DP1PfhVjdp8uYBXLo0feWSBwQRH7lopG3JEl_ffF3KsDFXprFrlzgjy_oS2Uy68kVSuWMbpPUd0CvZlSnVRLb-V1yaoTLE5f5JYwYlfgjzk-nnyWnYj1kIFcK1NrRJJOOodGF8qVgsKbNUqdRwRHJlmtu8dPM5OE-VFcLoiBkVxRoJeRQZi0HuIzioV7V5AiQSliMeENQIQWMb5w5iGC1UmSmmOQ8gHphbqL4HuRuFURV-LzzNi04gBQqk8AIp0gBebZ656jpw_JP62MlsQ-m6Z_sLq-ai6I2xyFkpMYwzudYx1ZpJjONEqZLUJkqXqQ3gaJB4MWhkkaBrQNfBqAjgxeY2GqPjsqzNau1pRJag_88CeNwpyGYlCBciV7YbAN9Sna2lbt-pl198w28EVeizaACvByX7tay_s-Lp_5E_g9uJtwMWRvkRHLTN2jxHwNWWI9jnCz6Cw_F49mmG38fT8w8f8eqETUY-iTHyduY-f0x_AujELU8
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLZKEYILYi2BAkaCE0R1HGfxASG2akqXUyvNzTheylRDZshkhPqn-I285yRTDUtvvU6cyOP3nt_3dkJeZi4DJSJszMGeiEXOTVwJCXLlnDSJ9kZqrHc-PMpHJ-LLOBtvkF9DLQymVQ53Yrio7cygj3yHg2SC5OZCvpv_iHFqFEZXhxEaHVvsu_OfYLIt3u59Avq-4nz38_HHUdxPFYgNoJM29pzphFVotVYmT7TIvTAmdQUAlyotfVnhOIqiSI2X0lmWO8MSCwsLxpwHmw6-e41cB8XL0NgrxsXKp8PSFCFEX5vD0nJnIRKBVUIc85ZKzERY039hTMC_sO3fKZp_xGmD-tu9Q273uJW-7xjtLtlw9T1yo5tkeX6fnGEYYIrOCQqIkp422rd0Apaz-z7RcePmrvFLdMzRSX0GZKRdeSSdYloIbUOH9anuyqBqqtvwFXRjTB3F2AJt3CAkD8jJlRz4Q7JZz2r3iFAmfQF4QwonpUh8UiKEcVaaKjO5LYqIJMPhKtP3OMdRG1MVYu1pqTqCKCCICgRRaURer96Zdx0-Ll39AWm2WonducMPs-ZU9cKuyrzSYCa60tpEWJtrsBNlZXjqubFV6iOyPVBc9VfGQl0weERerB6DsOMp69rNlmGNzDjgiywiWx2DrHYCcIRhWXBEijXWWdvq-pN68i00FAfQBjpRROTNwGQX2_r_UTy-_F88JzdHx4cH6mDvaP8JucWDDOQxK7fJZtss3VMAc231LEgQJV-vWmR_A6XjWwo
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zb9NAEB6VVCBeEDeGAosET2DFXq-PfUCI0kYthahCVOrb1t6jpApOcByh_jV-HTM-UoWjb32N19ZmZ77db64dgJexjfEQEcbnaE_4IuHaL4REXFkrdZg7LXOqd_48TvaOxMfj-HgDfvW1MJRW2e-JzUZtZpp85EOOyETkJkIOXZcWcbgzejf_4VMHKYq09u00WhU5sOc_0XxbvN3fQVm_4ny0-_XDnt91GPA1MpXadzzIw6AgC7bQSZiLxAmtI5siiSmizGUFtaZI00g7Ka0JEquD0ODANAisQ_sOv3sNNlOyigawub07Pvyy8vAEUUSEoqvUCaJsuBChoJohTllMGeUlrJ2GTdOAfzHdvxM2_4jaNofh6Dbc6lgse9-q3R3YsOVduN72tTy_B2cUFJiSq4Ihv2SnVe5qNkE72n6f5H5l57ZyS3LTsUl5hkJlbbEkm1KSCKub-9aneVsUVbK8br5CTo2pZRRpYJXtIXMfjq5kyR_AoJyV9hGwQLoU2YcUVkoRujAjQmON1EWsE5OmHoT94ird3XhOjTemqom8R5lqBaJQIKoRiIo8eL16Z97e93Hp6G2S2Wok3dXd_DCrTlUHfZUlRY5Go82MCYUxSY5Woyw0jxzXpoicB1u9xFW3gSzUhbp78GL1GKFPq5yXdrZsxsiYI9uIPXjYKshqJkhOAioS9iBdU521qa4_KSffmuvFkcLhCSk8eNMr2cW0_r8Ujy__F8_hBsJVfdofHzyBm7yBQOIH2RYM6mppnyKzq4tnHYQYnFw1an8D0eJgpQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Resolving+the+graft+ischemia-reperfusion+injury+during+liver+transplantation+at+the+single+cell+resolution&rft.jtitle=Cell+death+%26+disease&rft.au=Wang%2C+Linhe&rft.au=Li%2C+Jie&rft.au=He%2C+Shuai&rft.au=Liu%2C+Yang&rft.date=2021-06-08&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-4889&rft.volume=12&rft.issue=6&rft_id=info:doi/10.1038%2Fs41419-021-03878-3&rft.externalDocID=10_1038_s41419_021_03878_3
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-4889&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-4889&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-4889&client=summon