Therapeutic drug monitoring of oral targeted antineoplastic drugs

• Published in: European journal of clinical pharmacology Vol. 77; no. 4; pp. 441 - 464
• Main Authors: Mueller-Schoell, Anna, Groenland, Stefanie L., Scherf-Clavel, Oliver, van Dyk, Madelé, Huisinga, Wilhelm, Michelet, Robin, Jaehde, Ulrich, Steeghs, Neeltje, Huitema, Alwin D.R., Kloft, Charlotte
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2021; Springer Nature B.V
• Subjects: Adverse events; Antineoplastic drugs; Biomedical and Life Sciences; Biomedicine; Dosage; Dose-response effects; Drug dosages; Imatinib; Inhibitor drugs; Pharmacokinetics; Pharmacology/Toxicology; Review; Risk factors; Tamoxifen; Targeted cancer therapy; Therapeutic drug monitoring; Toxicity; Therapeutic drug monitoring; Personalised medicine; Targeted antineoplastic drugs; Oral anticancer drugs; Tyrosine kinase inhibitors

Purpose This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM). Factors influencing the pharmacokinetic exposure in OAD therapy are depicted together with an overview of diff...