The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway

• Published in: Scientific reports Vol. 11; no. 1; pp. 19737 - 10
• Main Authors: Dong, Xiao-Liu, Wang, Yan-Hui, Xu, Jing, Zhang, Nan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 692/617; AMP-activated protein kinase; AMP-Activated Protein Kinases - metabolism; Animals; Apoptosis; Apoptosis - drug effects; Astrocytes - drug effects; Astrocytes - metabolism; Biomarkers; Blood-brain barrier; Central nervous system; Cerebral Hemorrhage - diagnosis; Cerebral Hemorrhage - drug therapy; Cerebral Hemorrhage - etiology; Cerebral Hemorrhage - metabolism; Collagen; Collagenase; Cyclic AMP; Cyclic AMP - metabolism; Cytokines; Disease Models, Animal; Edema; Hemorrhage; Humanities and Social Sciences; Inactivation; Inflammation; Kinases; Male; Mice; multidisciplinary; Neuroglia - drug effects; Neuroglia - metabolism; Neurons - drug effects; Neurons - metabolism; Neuroprotection; Phosphodiesterase; Phosphodiesterase 4 Inhibitors - pharmacology; Phosphodiesterase 4 Inhibitors - therapeutic use; Phosphodiesterase IV; Phosphorylation; Rolipram; Rolipram - pharmacology; Rolipram - therapeutic use; Science; Science (multidisciplinary); Signal Transduction - drug effects; SIRT1 protein; Sirtuin 1 - metabolism

Rolipram specifically inhibits phosphodiesterase (PDE) 4, thereby preventing inactivation of the intracellular second messenger cyclic adenosine monophosphate (cAMP). Rolipram has been shown to play a neuroprotective role in some central nervous system (CNS) diseases. However, the role of PDE4 and t...