Direct and indirect consequences of meiotic recombination: implications for genome evolution

• Published in: Trends in genetics Vol. 28; no. 3; pp. 101 - 109
• Main Authors: Webster, Matthew T, Hurst, Laurence D
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.03.2012; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell cycle, cell proliferation; Cell physiology; Evolution, Molecular; Fundamental and applied biological sciences. Psychology; Genetic Fitness; Genetics of eukaryotes. Biological and molecular evolution; Genic rearrangement. Recombination. Transposable element; Genome; Humans; Medical Education; Meiosis; Molecular and cellular biology; Molecular genetics; Recombination, Genetic; Selection, Genetic; Molecular evolution; Genetics; Recombination; Meiosis

There is considerable variation within eukaryotic genomes in the local rate of crossing over. Why is this and what effect does it have on genome evolution? On the genome scale, it is known that by shuffling alleles, recombination increases the efficacy of selection. By contrast, the extent to which...