Direct and indirect consequences of meiotic recombination: implications for genome evolution

There is considerable variation within eukaryotic genomes in the local rate of crossing over. Why is this and what effect does it have on genome evolution? On the genome scale, it is known that by shuffling alleles, recombination increases the efficacy of selection. By contrast, the extent to which...

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Published inTrends in genetics Vol. 28; no. 3; pp. 101 - 109
Main Authors Webster, Matthew T, Hurst, Laurence D
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Ltd 01.03.2012
Elsevier
Subjects
Animals
Biological and medical sciences
Cell cycle, cell proliferation
Cell physiology
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genetic Fitness
Genetics of eukaryotes. Biological and molecular evolution
Genic rearrangement. Recombination. Transposable element
Genome
Humans
Medical Education
Meiosis
Molecular and cellular biology
Molecular genetics
Recombination, Genetic
Selection, Genetic
Molecular evolution
Genetics
Recombination
Meiosis
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Abstract There is considerable variation within eukaryotic genomes in the local rate of crossing over. Why is this and what effect does it have on genome evolution? On the genome scale, it is known that by shuffling alleles, recombination increases the efficacy of selection. By contrast, the extent to which differences in the recombination rate modulate the efficacy of selection between genomic regions is unclear. Recombination also has direct consequences on the origin and fate of mutations: biased gene conversion and other forms of meiotic drive promote the fixation of mutations in a similar way to selection, and recombination itself may be mutagenic. Consideration of both the direct and indirect effects of recombination is necessary to understand why its rate is so variable and for correct interpretation of patterns of genome evolution.
AbstractList There is considerable variation within eukaryotic genomes in the local rate of crossing over. Why is this and what effect does it have on genome evolution? On the genome scale, it is known that by shuffling alleles, recombination increases the efficacy of selection. By contrast, the extent to which differences in the recombination rate modulate the efficacy of selection between genomic regions is unclear. Recombination also has direct consequences on the origin and fate of mutations: biased gene conversion and other forms of meiotic drive promote the fixation of mutations in a similar way to selection, and recombination itself may be mutagenic. Consideration of both the direct and indirect effects of recombination is necessary to understand why its rate is so variable and for correct interpretation of patterns of genome evolution.
Author Hurst, Laurence D
Webster, Matthew T
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Issue 3
Keywords Molecular evolution
Genetics
Recombination
Meiosis
Language English
License CC BY 4.0
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Snippet There is considerable variation within eukaryotic genomes in the local rate of crossing over. Why is this and what effect does it have on genome evolution? On...
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SubjectTerms Animals
Biological and medical sciences
Cell cycle, cell proliferation
Cell physiology
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genetic Fitness
Genetics of eukaryotes. Biological and molecular evolution
Genic rearrangement. Recombination. Transposable element
Genome
Humans
Medical Education
Meiosis
Molecular and cellular biology
Molecular genetics
Recombination, Genetic
Selection, Genetic
Title Direct and indirect consequences of meiotic recombination: implications for genome evolution
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https://dx.doi.org/10.1016/j.tig.2011.11.002
https://www.ncbi.nlm.nih.gov/pubmed/22154475
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173484
Volume 28
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