Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis

• Published in: Scientific reports Vol. 11; no. 1; pp. 5925 - 11
• Main Authors: Silveira, Marcelo Augusto Duarte, Capcha, José Manuel Condor, Sanches, Talita Rojas, de Sousa Moreira, Roberto, Garnica, Margot S., Shimizu, Maria Heloisa, Berretta, Andresa, Teles, Flávio, Noronha, Irene L., Andrade, Lúcia
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/254; 631/443/272; Acute Kidney Injury - etiology; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Acute Kidney Injury - prevention & control; Acute Lung Injury - etiology; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Acute Lung Injury - prevention & control; Animal models; Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibiotics; Antioxidants; Apoptosis; Biomarkers; Blood levels; Cecum; Chemotaxis, Leukocyte - immunology; Chromatography, High Pressure Liquid; Clinical trials; Cytokines; Cytokines - metabolism; Cytology; Disease Models, Animal; DNA nucleotidylexotransferase; Glutathione; Humanities and Social Sciences; Immunomodulation; Inflammation; Kidney Function Tests; Kidneys; Lungs; Macrophages; Macrophages - immunology; Macrophages - metabolism; Macrophages - pathology; Mitochondria; multidisciplinary; NF-κB protein; Oxidative Stress - drug effects; Propolis; Propolis - chemistry; Protective Agents - pharmacology; Rats; Renal function; Rodents; Science; Science (multidisciplinary); Sepsis; Sepsis - complications; Signal Transduction; TLR4 protein; Toll-like receptors

Sepsis is the leading cause of acute kidney injury (AKI) and lung injury worldwide. Despite therapeutic advances, sepsis continues to be associated with high mortality. Because Brazilian green propolis (GP) has promising anti-inflammatory, antioxidant, and immunomodulatory properties, we hypothesize...