Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

• Published in: Nature communications Vol. 12; no. 1; pp. 4733 - 16
• Main Authors: Du, Xinchen, Wu, Le, Yan, Hongyu, Jiang, Zhuyan, Li, Shilin, Li, Wen, Bai, Yanli, Wang, Hongjun, Cheng, Zhaojun, Kong, Deling, Wang, Lianyong, Zhu, Meifeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/107; 631/443/1338/2729; 631/61/2035; 631/61/54/990; 639/166/985; Alkylation; Animal models; Animals; Antiinfectives and antibacterials; Bacterial Infections - prevention & control; Battlefields; Blood Coagulation; Chitosan; Chitosan - analogs & derivatives; Chitosan - chemistry; Coagulants; E coli; Engineers; Freeze drying; Gauze; Gelatin; Hemorrhage; Hemorrhage - therapy; Hemostatic Techniques - instrumentation; Hepatocytes; Humanities and Social Sciences; In situ leaching; Leaching; Liver; Liver - injuries; Liver Diseases - pathology; Liver Diseases - therapy; Liver Regeneration; Male; Materials Testing; Microchannels; Microfibers; Microscopy, Electron, Scanning; multidisciplinary; Porosity; Rats; Regeneration; Science; Science (multidisciplinary); Shape memory; Sponges; Surgical Sponges; Swine; Swine, Miniature; Three dimensional printing; Tissue engineering; Vascularization; Wound Healing

Developing an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D print...