A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation

The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their differentiation and morphogenesis into a functional ductal...

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Published inNature communications Vol. 10; no. 1; pp. 5220 - 15
Main Authors Thestrup, M. Ilcim, Caviglia, Sara, Cayuso, Jordi, Heyne, Ronja L. S., Ahmad, Racha, Hofmeister, Wolfgang, Satriano, Letizia, Wilkinson, David G., Andersen, Jesper B., Ober, Elke A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.11.2019
Nature Publishing Group
Nature Portfolio
Subjects
13/51
14
14/19
38
38/1
45
45/41
49/61
59
631/136
631/80
64
64/116
692/4020
Animals
Animals, Genetically Modified
Bile
Bile Ducts - embryology
Bile Ducts - metabolism
Cell Differentiation - genetics
Contractility
Ducts
Ephrin-B1 - genetics
Ephrin-B1 - metabolism
Ephrin-B3 - genetics
Ephrin-B3 - metabolism
Gene Expression Profiling
Hepatopancreas - embryology
Hepatopancreas - metabolism
Humanities and Social Sciences
Intestine
Ligands
Morphogenesis
Morphogenesis - genetics
multidisciplinary
Mutation
Myosin
Pancreas
Protein Binding
Receptors
Receptors, Eph Family - genetics
Receptors, Eph Family - metabolism
Science
Science (multidisciplinary)
Sensory neurons
Signal Transduction - genetics
Zebrafish
Zebrafish - embryology
Zebrafish - genetics
Zebrafish - metabolism
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
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Abstract The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their differentiation and morphogenesis into a functional ductal system are poorly understood. Here, we characterize HPD system morphogenesis by high-resolution microscopy in zebrafish. The HPD system differentiates from a rod of unpolarized cells into mature ducts by de novo lumen formation in a dynamic multi-step process. The remodeling step from multiple nascent lumina into a single lumen requires active cell intercalation and myosin contractility. We identify key functions for EphB/EphrinB signaling in this dynamic remodeling step. Two EphrinB ligands, EphrinB1 and EphrinB2a, and two EphB receptors, EphB3b and EphB4a, control HPD morphogenesis by remodeling individual ductal compartments, and thereby coordinate the morphogenesis of this multi-compartment ductal system. The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the authors describe how regionalised Eph/Ephrin signaling regulates HPD morphogenesis by promoting cellular rearrangements leading to an open tube.
AbstractList The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their differentiation and morphogenesis into a functional ductal system are poorly understood. Here, we characterize HPD system morphogenesis by high-resolution microscopy in zebrafish. The HPD system differentiates from a rod of unpolarized cells into mature ducts by de novo lumen formation in a dynamic multi-step process. The remodeling step from multiple nascent lumina into a single lumen requires active cell intercalation and myosin contractility. We identify key functions for EphB/EphrinB signaling in this dynamic remodeling step. Two EphrinB ligands, EphrinB1 and EphrinB2a, and two EphB receptors, EphB3b and EphB4a, control HPD morphogenesis by remodeling individual ductal compartments, and thereby coordinate the morphogenesis of this multi-compartment ductal system.
The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the authors describe how regionalised Eph/Ephrin signaling regulates HPD morphogenesis by promoting cellular rearrangements leading to an open tube.
The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their differentiation and morphogenesis into a functional ductal system are poorly understood. Here, we characterize HPD system morphogenesis by high-resolution microscopy in zebrafish. The HPD system differentiates from a rod of unpolarized cells into mature ducts by de novo lumen formation in a dynamic multi-step process. The remodeling step from multiple nascent lumina into a single lumen requires active cell intercalation and myosin contractility. We identify key functions for EphB/EphrinB signaling in this dynamic remodeling step. Two EphrinB ligands, EphrinB1 and EphrinB2a, and two EphB receptors, EphB3b and EphB4a, control HPD morphogenesis by remodeling individual ductal compartments, and thereby coordinate the morphogenesis of this multi-compartment ductal system. The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the authors describe how regionalised Eph/Ephrin signaling regulates HPD morphogenesis by promoting cellular rearrangements leading to an open tube.
Abstract The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their differentiation and morphogenesis into a functional ductal system are poorly understood. Here, we characterize HPD system morphogenesis by high-resolution microscopy in zebrafish. The HPD system differentiates from a rod of unpolarized cells into mature ducts by de novo lumen formation in a dynamic multi-step process. The remodeling step from multiple nascent lumina into a single lumen requires active cell intercalation and myosin contractility. We identify key functions for EphB/EphrinB signaling in this dynamic remodeling step. Two EphrinB ligands, EphrinB1 and EphrinB2a, and two EphB receptors, EphB3b and EphB4a, control HPD morphogenesis by remodeling individual ductal compartments, and thereby coordinate the morphogenesis of this multi-compartment ductal system.
ArticleNumber 5220
Author Cayuso, Jordi
Heyne, Ronja L. S.
Thestrup, M. Ilcim
Satriano, Letizia
Ahmad, Racha
Andersen, Jesper B.
Hofmeister, Wolfgang
Ober, Elke A.
Caviglia, Sara
Wilkinson, David G.
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SSID ssj0000391844
Score 2.4342232
Snippet The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile...
Abstract The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of...
The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the...
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pubmedcentral
proquest
crossref
pubmed
springer
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Open Access Repository
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Index Database
Publisher
StartPage 5220
SubjectTerms 13/51
14
14/19
38
38/1
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49/61
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631/136
631/80
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692/4020
Animals
Animals, Genetically Modified
Bile
Bile Ducts - embryology
Bile Ducts - metabolism
Cell Differentiation - genetics
Contractility
Ducts
Ephrin-B1 - genetics
Ephrin-B1 - metabolism
Ephrin-B3 - genetics
Ephrin-B3 - metabolism
Gene Expression Profiling
Hepatopancreas - embryology
Hepatopancreas - metabolism
Humanities and Social Sciences
Intestine
Ligands
Morphogenesis
Morphogenesis - genetics
multidisciplinary
Mutation
Myosin
Pancreas
Protein Binding
Receptors
Receptors, Eph Family - genetics
Receptors, Eph Family - metabolism
Science
Science (multidisciplinary)
Sensory neurons
Signal Transduction - genetics
Zebrafish
Zebrafish - embryology
Zebrafish - genetics
Zebrafish - metabolism
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
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Title A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation
URI https://link.springer.com/article/10.1038/s41467-019-13149-7
https://www.ncbi.nlm.nih.gov/pubmed/31745086
https://www.proquest.com/docview/2315956639
https://search.proquest.com/docview/2316425448
https://pubmed.ncbi.nlm.nih.gov/PMC6864101
https://doaj.org/article/d573b8c9777949828bdc150f56bc1b0b
Volume 10
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