Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition

• Published in: Nature communications Vol. 9; no. 1; pp. 2504 - 16
• Main Authors: Jiao, Jiantong, Zhang, Rui, Li, Zheng, Yin, Ying, Fang, Xiangming, Ding, Xiaopeng, Cai, Ying, Yang, Shudong, Mu, Huijun, Zong, Da, Chen, Yuexin, Zhang, Yansong, Zou, Jian, Shao, Junfei, Huang, Zhaohui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.06.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13/105; 13/51; 13/95; 631/67/1922; 631/67/2195; 82/80; Adult; Aged; Aged, 80 and over; Animals; Brain; Brain - pathology; Brain Neoplasms - genetics; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Carcinogenesis - pathology; Cell Line, Tumor; Cell Nucleus - metabolism; Cell Proliferation - genetics; Cohort Studies; Degradation; Down-Regulation; Female; Gene expression; Gene Expression Regulation, Neoplastic; Glioma; Glioma - genetics; Glioma - mortality; Glioma - pathology; Glioma cells; Growth factors; HEK293 Cells; Homology; Hospitals; Humanities and Social Sciences; Humans; Infant; Kinases; Localization; Male; Medical prognosis; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Molecular chains; Molecular Chaperones - metabolism; multidisciplinary; Neurosurgery; Nuclei; Nuclei (cytology); Pathology; Patients; Protein Domains; Protein expression; Protein Inhibitors of Activated STAT - metabolism; Proteins; Proteolysis; Rings (mathematics); Science; Science (multidisciplinary); Signal Transduction - genetics; Smad6 Protein - metabolism; Stat3 protein; STAT3 Transcription Factor - metabolism; Survival Rate; Transcription activation; Tumorigenesis; Tumors; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitination - genetics; Up-Regulation; Xenograft Model Antitumor Assays; Young Adult

To date, the molecular mechanism underlying constitutive signal transducer and activator of transcription 3 (STAT3) activation in gliomas is largely unclear. In this study, we report that Smad6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT...