Motor unit number index (MUNIX) loss of 50% occurs in half the time of 50% functional loss according to the D50 disease progression model of ALS

• Published in: Scientific reports Vol. 13; no. 1; pp. 3981 - 10
• Main Authors: Ebersbach, Theresa, Roediger, Annekathrin, Steinbach, Robert, Appelfeller, Martin, Tuemmler, Anke, Stubendorff, Beatrice, Axer, Hubertus, Witte, Otto W., Grosskreutz, Julian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/53; 692/617/375/1917; 692/617/375/1917/1285; 692/617/375/364; Action potential; Action Potentials - physiology; Amyotrophic Lateral Sclerosis; Arm; Disease Progression; Electromyography; Humanities and Social Sciences; Humans; multidisciplinary; Muscle, Skeletal; Science; Science (multidisciplinary)

Capturing disease progression in amyotrophic lateral sclerosis (ALS) is challenging and refinement of progression markers is urgently needed. This study introduces new motor unit number index (MUNIX), motor unit size index (MUSIX) and compound muscle action potential (CMAP) parameters called M50, MU...