Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range

• Published in: Scientific reports Vol. 11; no. 1; pp. 15927 - 9
• Main Authors: Winkley, Konner, Banerjee, Dithi, Bradley, Todd, Koseva, Boryana, Cheung, Warren A., Selvarangan, Rangaraj, Pastinen, Tomi, Grundberg, Elin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/191; 631/250/347; Adolescent; Adult; Age; Antiviral activity; Antiviral drugs; Child; Child, Preschool; COVID-19; COVID-19 - genetics; COVID-19 - immunology; Epithelial cells; Female; Humanities and Social Sciences; Humans; Immune response; Immune system; Immunity, Cellular; Immunity, Innate; Immunization; Infant; Innate immunity; Life span; Lymphocytes T; Male; Middle Aged; Mucosa; multidisciplinary; Nasal Mucosa - cytology; Nasal Mucosa - immunology; Nasal Mucosa - metabolism; Respiratory diseases; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Transcription; Transcriptome; Young Adult

Previous studies focusing on the age disparity in COVID-19 severity have suggested that younger individuals mount a more robust innate immune response in the nasal mucosa after infection with SARS-CoV-2. However, it is unclear if this reflects increased immune activation or increased immune residenc...