EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells

• Published in: Scientific reports Vol. 10; no. 1; p. 9275
• Main Authors: Yoshino, Seiko, Matsui, Yusuke, Fukui, Yuya, Seki, Masahide, Yamaguchi, Kiyoshi, Kanamori, Akane, Saitoh, Yurika, Shimamura, Teppei, Suzuki, Yutaka, Furukawa, Yoichi, Kaneko, Shuichi, Seiki, Motoharu, Murakami, Yoshinori, Inoue, Jun-ichiro, Sakamoto, Takeharu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.06.2020; Nature Publishing Group
• Subjects: 631/67; 631/67/1059/2326; Adaptation; Animals; APOBEC-3G Deaminase - genetics; APOBEC-3G Deaminase - metabolism; Binding Sites; Cancer; Cell Line, Tumor; Cytoplasmic Structures - metabolism; DNA Damage; Drug delivery; Endoplasmic Reticulum Stress; Exosome Multienzyme Ribonuclease Complex - genetics; Exosome Multienzyme Ribonuclease Complex - metabolism; Exosomes - genetics; Exosomes - metabolism; Female; Gene expression; Gene regulation; Humanities and Social Sciences; Humans; Medical prognosis; Mice, Inbred BALB C; multidisciplinary; Oxidative Stress; Ribonucleic acid; RNA; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Science; Science (multidisciplinary); Stress, Physiological - physiology; Transcription; Tumorigenicity; Xenograft Model Antitumor Assays; Xenografts

Cancer cells adapt to various stress conditions by optimizing gene expression profiles via transcriptional and translational regulation. However, whether and how EXOSC9, a component of the RNA exosome complex, regulates adaptation to stress conditions and tumorigenicity in cancer cells remain unclea...