Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts

• Published in: Scientific reports Vol. 9; no. 1; pp. 13637 - 17
• Main Authors: Takeda, Tomoya, Doiyama, Sota, Azumi, Junya, Shimada, Yasuhiro, Tokuji, Yoshihiko, Yamaguchi, Hiroaki, Nagata, Kosuke, Sakamoto, Naoya, Aso, Hisashi, Nakamura, Takashi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.09.2019; Nature Publishing Group
• Subjects: 38/61; 631/80/2373; 631/80/82; Antioxidants; Apoptosis; Ascorbic acid; Cell death; Cell Death - drug effects; Cells, Cultured; Chemokines; Chromatography, Liquid; Cosmetics; Dose-Response Relationship, Drug; Fibroblasts; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene Expression Regulation - drug effects; Germanium; Humanities and Social Sciences; Humans; Hydrogen peroxide; Hydrolysis; Hypoxanthine; Hypoxanthine - metabolism; Inflammation; Interleukin 6; Interleukin-6 - genetics; Isotope Labeling; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Microscopy; Mortality; multidisciplinary; Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Oxidative stress; Oxidative Stress - drug effects; Polymers; Reactive oxygen species; Science; Science (multidisciplinary); Skin; Skin - cytology; Skin - drug effects; Skin - metabolism; Tandem Mass Spectrometry; Xanthine oxidase; Xanthine Oxidase - metabolism

Reactive oxygen species (ROS) are very harmful to dermal cells, and it is thus important to develop cosmetics that protect the skin from ROS and other stimuli. Repagermanium is a synthetic water-soluble organogermanium polymer, and in this study, we attempted to visualize the incorporation of german...