A comprehensive analysis of clinical outcomes in lung cancer patients harboring a MET exon 14 skipping mutation compared to other driver mutations in an East Asian population

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 103; pp. 82 - 89
• Main Authors: Gow, Chien-Hung, Hsieh, Min-Shu, Wu, Shang-Gin, Shih, Jin-Yuan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.01.2017
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Anaplastic Lymphoma Kinase; Asian Continental Ancestry Group - genetics; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Disease-Free Survival; Driver mutation; ErbB Receptors - genetics; Exons; Female; Hematology, Oncology and Palliative Medicine; Humans; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; MET exon 14 skipping; Middle Aged; Mutation; Oncogene Proteins, Fusion - genetics; One-step reverse transcriptase-polymerase chain reaction; Overall survival; Protein Kinase Inhibitors - therapeutic use; Protein-Tyrosine Kinases - genetics; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins c-met - genetics; Proto-Oncogene Proteins c-met - metabolism; Proto-Oncogene Proteins p21(ras) - genetics; Pulmonary/Respiratory; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2 - genetics; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction - methods; Taiwan - epidemiology; Taiwan; ADC; Driver mutation; SCC; One-step reverse transcriptase-polymerase chain reaction; OS; IHC; Lung cancer; MET exon 14 skipping; Overall survival; MET; METΔ14; MET proto-oncogene, receptor tyrosine kinase; adenocarcinoma; MET Δ14; overall survival; immunohistochemistry; squamous cell carcinoma

•We detected METΔ14 and five other major driver mutations in lung cancer patients.•METΔ14 mutation can be successfully detected in a one-step RT-PCR using RNA samples.•METΔ14 mutation positive samples exhibited a strong cytoplasmic expression of MET.•Stage IV METΔ14 positive and driver mutation nega...