CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease

• Published in: Nature communications Vol. 12; no. 1; pp. 7172 - 11
• Main Authors: Duan, Yi, Chu, Huikuan, Brandl, Katharina, Jiang, Lu, Zeng, Suling, Meshgin, Nairika, Papachristoforou, Eleni, Argemi, Josepmaria, Mendes, Beatriz G., Wang, Yanhan, Su, Hua, Sun, Weizhong, Llorente, Cristina, Hendrikx, Tim, Liu, Xiao, Hosseini, Mojgan, Kisseleva, Tatiana, Brenner, David A., Bataller, Ramon, Ramachandran, Prakash, Karin, Michael, Fu, Wenxian, Schnabl, Bernd
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/2504/342; 64/60; 692/308/575; 692/699/1503/1607/1608; Animals; Bacteria; Bacterial Translocation; Complement C3b - immunology; Complement component C3b; Enterococcus faecalis; Enterococcus faecalis - immunology; Enterococcus faecalis - physiology; Ethanol; Ethanol - adverse effects; Female; Gastrointestinal Tract - microbiology; Gram-positive bacteria; Gram-Positive Bacterial Infections - genetics; Gram-Positive Bacterial Infections - immunology; Gram-Positive Bacterial Infections - microbiology; Homeostasis; Humanities and Social Sciences; Humans; Immune clearance; Immunoglobulins; Liver; Liver - drug effects; Liver - immunology; Liver - microbiology; Liver diseases; Liver Diseases, Alcoholic - etiology; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - immunology; Liver Diseases, Alcoholic - microbiology; Macrophages; Macrophages - immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Phagocytes; Phagocytosis; Receptors; Receptors, Complement - deficiency; Receptors, Complement - genetics; Receptors, Complement - immunology; Receptors, Complement 3b - genetics; Receptors, Complement 3b - immunology; Rodents; Science; Science (multidisciplinary); Toll-like receptors

Complement receptor of immunoglobulin superfamily (CRIg) is expressed on liver macrophages and directly binds complement component C3b or Gram-positive bacteria to mediate phagocytosis. CRIg plays important roles in several immune-mediated diseases, but it is not clear how its pathogen recognition a...