Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis

• Published in: Cell death & disease Vol. 12; no. 3; pp. 263 - 12
• Main Authors: Nardacci, Roberta, Colavita, Francesca, Castilletti, Concetta, Lapa, Daniele, Matusali, Giulia, Meschi, Silvia, Del Nonno, Franca, Colombo, Daniele, Capobianchi, Maria Rosaria, Zumla, Alimuddin, Ippolito, Giuseppe, Piacentini, Mauro, Falasca, Laura
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.03.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13; 13/51; 14; 14/1; 14/19; 14/28; 14/63; 692/420/254; 692/699/255/2514; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Chlorocebus aethiops; Cholesterol; Coronaviruses; COVID-19; COVID-19 - metabolism; COVID-19 - pathology; Cytopathogenesis; Cytopathogenic Effect, Viral; Drug therapy; Homeostasis; Humans; Immunology; Life Sciences; Lipid Droplets - ultrastructure; Lipid Droplets - virology; Lipid Metabolism; Lipids; Lung - metabolism; Lung - ultrastructure; Lung - virology; Lungs; Mitochondria; Pathogenesis; Pathogenicity; Pneumocytes; SARS-CoV-2 - metabolism; SARS-CoV-2 - ultrastructure; Severe Acute Respiratory Syndrome - metabolism; Severe Acute Respiratory Syndrome - pathology; Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus - metabolism; Severe acute respiratory syndrome-related coronavirus - ultrastructure; Vacuoles; Vero Cells

The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-CoV-2 cellular cytopathic effects requires definition. We performed a comparative ultrastructural study of SARS-CoV-1 and SARS-CoV-2 infection in Vero E6 cells and in lungs from deceased COVID-19 patients. SARS-CoV...