Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we fin...
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| Published in | Nature communications Vol. 11; no. 1; pp. 984 - 9 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Nature Publishing Group UK
20.02.2020
Nature Publishing Group Nature Portfolio |
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| Abstract | Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator
Srebp2
and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective promoter activation. |
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| AbstractList | Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states. Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective promoter activation. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states.Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states. Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective promoter activation. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states.Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective promoter activation. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular localization and transport of RNA. Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. In vivo interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulating cholesterogenesis. Interestingly, we find that RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Our work offers insights into mechanisms orchestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact health and disease states. |
| ArticleNumber | 984 |
| Author | Lee, Brennan Wu, Xiaohui Wang, Dan Zhang, Zhengyi Williams, Kevin J. Scumpia, Phil Feng, An-Chieh Pan, Calvin Sallam, Tamer Salisbury, David Fraga, Josue Lusis, Aldons J. Lapina, Irina Liu, Xin Kim, Jason |
| Author_xml | – sequence: 1 givenname: Zhengyi surname: Zhang fullname: Zhang, Zhengyi organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Institute, University of California – sequence: 2 givenname: An-Chieh surname: Feng fullname: Feng, An-Chieh organization: Molecular Biology Interdepartmental Doctoral Program, University of California, Division of Dermatology, Department of Medicine, University of California, Department of Microbiology, Immunology and Molecular Genetics, University of California – sequence: 3 givenname: David surname: Salisbury fullname: Salisbury, David organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Interdepartmental Doctoral Program, University of California – sequence: 4 givenname: Xin surname: Liu fullname: Liu, Xin organization: Molecular Biology Interdepartmental Doctoral Program, University of California – sequence: 5 givenname: Xiaohui surname: Wu fullname: Wu, Xiaohui organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Institute, University of California – sequence: 6 givenname: Jason surname: Kim fullname: Kim, Jason organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Institute, University of California – sequence: 7 givenname: Irina surname: Lapina fullname: Lapina, Irina organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Institute, University of California – sequence: 8 givenname: Dan surname: Wang fullname: Wang, Dan organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Institute, University of California – sequence: 9 givenname: Brennan surname: Lee fullname: Lee, Brennan organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Institute, University of California – sequence: 10 givenname: Josue surname: Fraga fullname: Fraga, Josue organization: Division of Cardiology, Department of Medicine, University of California – sequence: 11 givenname: Calvin orcidid: 0000-0002-0752-833X surname: Pan fullname: Pan, Calvin organization: Division of Cardiology, Department of Medicine, University of California, Department of Human Genetics, University of California – sequence: 12 givenname: Kevin J. surname: Williams fullname: Williams, Kevin J. organization: Department of Biological Chemistry, University of California – sequence: 13 givenname: Aldons J. orcidid: 0000-0001-9013-0228 surname: Lusis fullname: Lusis, Aldons J. organization: Division of Cardiology, Department of Medicine, University of California, Department of Human Genetics, University of California – sequence: 14 givenname: Phil surname: Scumpia fullname: Scumpia, Phil organization: Division of Dermatology, Department of Medicine, University of California – sequence: 15 givenname: Tamer surname: Sallam fullname: Sallam, Tamer email: tsallam@mednet.ucla.edu organization: Division of Cardiology, Department of Medicine, University of California, Molecular Biology Institute, University of California, Molecular, Cellular and Integrative Physiology Program, University of California |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32080181$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.tem.2011.10.004 10.1261/rna.053918.115 10.1093/hmg/ddy093 10.1016/j.cell.2009.02.011 10.1016/j.cmet.2011.03.005 10.1038/nrm3312 10.1016/j.cmet.2013.10.002 10.1093/nar/gkt448 10.1016/j.molcel.2011.08.018 10.1016/j.molcel.2010.05.004 10.1038/ng.3913 10.1007/s00439-016-1683-5 10.1042/BJ20091511 10.1038/ng.3874 10.1139/o59-099 10.1038/nm.4479 10.1371/journal.pgen.1000133 10.1074/jbc.271.40.24359 10.1093/ije/dyl309 10.1016/j.molcel.2017.02.013 10.1002/0471142727.mb2129s109 10.3389/fnins.2018.00326 10.1038/nature09784 10.1016/j.cell.2016.01.020 10.1172/JCI0215593 10.1038/nature17674 10.1261/rna.2254110 10.1016/j.neuron.2013.12.018 10.7554/eLife.25015 |
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| References | Zambelli, Pesole, Pavesi (CR29) 2013; 41 Wang, Chang (CR18) 2011; 43 Orozco (CR21) 2018; 27 Jeon, Osborne (CR10) 2012; 23 Seo (CR15) 2011; 13 Purice, Taylor (CR2) 2018; 12 Calkin, Tontonoz (CR8) 2012; 13 Ericsson, Jackson, Edwards (CR13) 1996; 271 Alami (CR23) 2014; 81 Nelson (CR5) 2017; 49 Ishimoto (CR12) 2010; 429 CR11 Chaudhury, Chander, Howe (CR14) 2010; 16 Rong (CR24) 2013; 18 Margueron, Reinberg (CR20) 2011; 469 Sallam (CR7) 2016; 534 Boeynaems (CR22) 2017; 65 Horton, Goldstein, Brown (CR9) 2002; 109 Davidovich, Cech (CR17) 2015; 21 Buenrostro, Wu, Chang, Greenleaf (CR19) 2015; 109 Bligh, Dyer (CR26) 1959; 37 Heinz (CR28) 2010; 38 Tong (CR27) 2016; 165 Reed, Charos, Szekely, Weissman, Snyder (CR16) 2008; 4 Howson (CR4) 2017; 49 Strachan (CR6) 2007; 36 Geuens, Bouhy, Timmerman (CR1) 2016; 135 Cooper, Wan, Dreyfuss (CR3) 2009; 136 Sallam (CR25) 2018; 24 EG Bligh (14711_CR26) 1959; 37 14711_CR11 T Geuens (14711_CR1) 2016; 135 AJ Tong (14711_CR27) 2016; 165 MD Purice (14711_CR2) 2018; 12 CP Nelson (14711_CR5) 2017; 49 J Ericsson (14711_CR13) 1996; 271 A Chaudhury (14711_CR14) 2010; 16 C Davidovich (14711_CR17) 2015; 21 T Sallam (14711_CR25) 2018; 24 JD Horton (14711_CR9) 2002; 109 KC Wang (14711_CR18) 2011; 43 LD Orozco (14711_CR21) 2018; 27 JMM Howson (14711_CR4) 2017; 49 JD Buenrostro (14711_CR19) 2015; 109 R Margueron (14711_CR20) 2011; 469 NH Alami (14711_CR23) 2014; 81 K Ishimoto (14711_CR12) 2010; 429 TI Jeon (14711_CR10) 2012; 23 T Sallam (14711_CR7) 2016; 534 F Zambelli (14711_CR29) 2013; 41 YK Seo (14711_CR15) 2011; 13 BD Reed (14711_CR16) 2008; 4 S Boeynaems (14711_CR22) 2017; 65 DP Strachan (14711_CR6) 2007; 36 S Heinz (14711_CR28) 2010; 38 AC Calkin (14711_CR8) 2012; 13 TA Cooper (14711_CR3) 2009; 136 X Rong (14711_CR24) 2013; 18 |
| References_xml | – volume: 23 start-page: 65 year: 2012 end-page: 72 ident: CR10 article-title: SREBPs: metabolic integrators in physiology and metabolism publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2011.10.004 – volume: 21 start-page: 2007 year: 2015 end-page: 2022 ident: CR17 article-title: The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2 publication-title: RNA doi: 10.1261/rna.053918.115 – volume: 27 start-page: 1830 year: 2018 end-page: 1846 ident: CR21 article-title: Epigenome-wide association in adipose tissue from the METSIM cohort publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddy093 – volume: 136 start-page: 777 year: 2009 end-page: 793 ident: CR3 article-title: RNA and disease publication-title: Cell doi: 10.1016/j.cell.2009.02.011 – volume: 13 start-page: 367 year: 2011 end-page: 375 ident: CR15 article-title: Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy publication-title: Cell Metab. doi: 10.1016/j.cmet.2011.03.005 – volume: 13 start-page: 213 year: 2012 end-page: 224 ident: CR8 article-title: Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3312 – volume: 18 start-page: 685 year: 2013 end-page: 697 ident: CR24 article-title: LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.10.002 – volume: 41 start-page: W535 year: 2013 end-page: W543 ident: CR29 article-title: PscanChIP: finding over-represented transcription factor-binding site motifs and their correlations in sequences from ChIP-Seq experiments publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt448 – volume: 43 start-page: 904 year: 2011 end-page: 914 ident: CR18 article-title: Molecular mechanisms of long noncoding RNAs publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.08.018 – volume: 38 start-page: 576 year: 2010 end-page: 589 ident: CR28 article-title: Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 – volume: 49 start-page: 1385 year: 2017 end-page: 1391 ident: CR5 article-title: Association analyses based on false discovery rate implicate new loci for coronary artery disease publication-title: Nat. Genet. doi: 10.1038/ng.3913 – volume: 135 start-page: 851 year: 2016 end-page: 867 ident: CR1 article-title: The hnRNP family: insights into their role in health and disease publication-title: Hum. Genet doi: 10.1007/s00439-016-1683-5 – volume: 429 start-page: 347 year: 2010 end-page: 357 ident: CR12 article-title: Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells publication-title: Biochem. J. doi: 10.1042/BJ20091511 – volume: 49 start-page: 1113 year: 2017 end-page: 1119 ident: CR4 article-title: Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms publication-title: Nat. Genet. doi: 10.1038/ng.3874 – volume: 37 start-page: 911 year: 1959 end-page: 917 ident: CR26 article-title: A rapid method of total lipid extraction and purification publication-title: Can. J. Biochem. Physiol. doi: 10.1139/o59-099 – volume: 24 start-page: 304 year: 2018 end-page: 312 ident: CR25 article-title: Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA publication-title: Nat. Med. doi: 10.1038/nm.4479 – volume: 4 start-page: e1000133 year: 2008 ident: CR16 article-title: Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000133 – ident: CR11 – volume: 271 start-page: 24359 year: 1996 end-page: 24364 ident: CR13 article-title: Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.40.24359 – volume: 36 start-page: 522 year: 2007 end-page: 531 ident: CR6 article-title: Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyl309 – volume: 65 start-page: 1044 year: 2017 end-page: 1055 e1045 ident: CR22 article-title: Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics publication-title: Mol. Cell doi: 10.1016/j.molcel.2017.02.013 – volume: 109 start-page: 21 year: 2015 end-page: 29 ident: CR19 article-title: ATAC-seq: a method for assaying chromatin accessibility genome-wide publication-title: Curr. Protoc. Mol. Biol. doi: 10.1002/0471142727.mb2129s109 – volume: 12 start-page: 326 year: 2018 ident: CR2 article-title: Linking hnRNP function to ALS and FTD pathology publication-title: Front. Neurosci. doi: 10.3389/fnins.2018.00326 – volume: 469 start-page: 343 year: 2011 end-page: 349 ident: CR20 article-title: The polycomb complex PRC2 and its mark in life publication-title: Nature doi: 10.1038/nature09784 – volume: 165 start-page: 165 year: 2016 end-page: 179 ident: CR27 article-title: A stringent systems approach uncovers gene-specific mechanisms regulating inflammation publication-title: Cell doi: 10.1016/j.cell.2016.01.020 – volume: 109 start-page: 1125 year: 2002 end-page: 1131 ident: CR9 article-title: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver publication-title: J. Clin. Invest. doi: 10.1172/JCI0215593 – volume: 534 start-page: 124 year: 2016 end-page: 128 ident: CR7 article-title: Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis publication-title: Nature doi: 10.1038/nature17674 – volume: 16 start-page: 1449 year: 2010 end-page: 1462 ident: CR14 article-title: Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: focus on hnRNP E1’s multifunctional regulatory roles publication-title: RNA doi: 10.1261/rna.2254110 – volume: 81 start-page: 536 year: 2014 end-page: 543 ident: CR23 article-title: Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations publication-title: Neuron doi: 10.1016/j.neuron.2013.12.018 – volume: 13 start-page: 213 year: 2012 ident: 14711_CR8 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3312 – volume: 24 start-page: 304 year: 2018 ident: 14711_CR25 publication-title: Nat. Med. doi: 10.1038/nm.4479 – volume: 37 start-page: 911 year: 1959 ident: 14711_CR26 publication-title: Can. J. Biochem. Physiol. doi: 10.1139/o59-099 – volume: 65 start-page: 1044 year: 2017 ident: 14711_CR22 publication-title: Mol. Cell doi: 10.1016/j.molcel.2017.02.013 – volume: 43 start-page: 904 year: 2011 ident: 14711_CR18 publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.08.018 – volume: 16 start-page: 1449 year: 2010 ident: 14711_CR14 publication-title: RNA doi: 10.1261/rna.2254110 – volume: 18 start-page: 685 year: 2013 ident: 14711_CR24 publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.10.002 – volume: 38 start-page: 576 year: 2010 ident: 14711_CR28 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 – volume: 271 start-page: 24359 year: 1996 ident: 14711_CR13 publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.40.24359 – volume: 429 start-page: 347 year: 2010 ident: 14711_CR12 publication-title: Biochem. J. doi: 10.1042/BJ20091511 – volume: 469 start-page: 343 year: 2011 ident: 14711_CR20 publication-title: Nature doi: 10.1038/nature09784 – volume: 165 start-page: 165 year: 2016 ident: 14711_CR27 publication-title: Cell doi: 10.1016/j.cell.2016.01.020 – volume: 4 start-page: e1000133 year: 2008 ident: 14711_CR16 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000133 – volume: 36 start-page: 522 year: 2007 ident: 14711_CR6 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyl309 – volume: 49 start-page: 1113 year: 2017 ident: 14711_CR4 publication-title: Nat. Genet. doi: 10.1038/ng.3874 – volume: 41 start-page: W535 year: 2013 ident: 14711_CR29 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt448 – volume: 23 start-page: 65 year: 2012 ident: 14711_CR10 publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2011.10.004 – ident: 14711_CR11 doi: 10.7554/eLife.25015 – volume: 136 start-page: 777 year: 2009 ident: 14711_CR3 publication-title: Cell doi: 10.1016/j.cell.2009.02.011 – volume: 135 start-page: 851 year: 2016 ident: 14711_CR1 publication-title: Hum. Genet doi: 10.1007/s00439-016-1683-5 – volume: 534 start-page: 124 year: 2016 ident: 14711_CR7 publication-title: Nature doi: 10.1038/nature17674 – volume: 109 start-page: 21 year: 2015 ident: 14711_CR19 publication-title: Curr. Protoc. Mol. Biol. doi: 10.1002/0471142727.mb2129s109 – volume: 27 start-page: 1830 year: 2018 ident: 14711_CR21 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddy093 – volume: 12 start-page: 326 year: 2018 ident: 14711_CR2 publication-title: Front. Neurosci. doi: 10.3389/fnins.2018.00326 – volume: 13 start-page: 367 year: 2011 ident: 14711_CR15 publication-title: Cell Metab. doi: 10.1016/j.cmet.2011.03.005 – volume: 81 start-page: 536 year: 2014 ident: 14711_CR23 publication-title: Neuron doi: 10.1016/j.neuron.2013.12.018 – volume: 109 start-page: 1125 year: 2002 ident: 14711_CR9 publication-title: J. Clin. Invest. doi: 10.1172/JCI0215593 – volume: 49 start-page: 1385 year: 2017 ident: 14711_CR5 publication-title: Nat. Genet. doi: 10.1038/ng.3913 – volume: 21 start-page: 2007 year: 2015 ident: 14711_CR17 publication-title: RNA doi: 10.1261/rna.053918.115 |
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| Snippet | Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular... Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for... |
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| Title | Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice |
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