Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis

We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27 th...

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Published inScientific reports Vol. 8; no. 1; pp. 5804 - 12
Main Authors Chu, Che-Sheng, Tseng, Ping-Tao, Stubbs, Brendon, Chen, Tien-Yu, Tang, Chia-Hung, Li, Dian-Jeng, Yang, Wei-Cheng, Chen, Yen-Wen, Wu, Ching-Kuan, Veronese, Nicola, Carvalho, Andre F., Fernandes, Brisa S., Herrmann, Nathan, Lin, Pao-Yen
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 11.04.2018
Nature Publishing Group
Subjects
692/308/174
692/499
Alzheimer's disease
Cognitive ability
Dementia
Dementia disorders
Humanities and Social Sciences
Lipophilic
Meta-analysis
multidisciplinary
Risk assessment
Science
Science (multidisciplinary)
Statins
Systematic review
Vascular dementia
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Abstract We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27 th , 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556–0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.
AbstractList We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27 th , 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556–0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.
We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer's disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787-0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576-0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556-0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620-1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818-0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383-1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449-0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475-1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer's disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787-0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576-0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556-0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620-1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818-0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383-1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449-0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475-1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.
We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer's disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27 , 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787-0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576-0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556-0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620-1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818-0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383-1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449-0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475-1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.
We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556–0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.
ArticleNumber 5804
Author Tseng, Ping-Tao
Chu, Che-Sheng
Lin, Pao-Yen
Tang, Chia-Hung
Fernandes, Brisa S.
Stubbs, Brendon
Chen, Tien-Yu
Li, Dian-Jeng
Carvalho, Andre F.
Herrmann, Nathan
Yang, Wei-Cheng
Wu, Ching-Kuan
Veronese, Nicola
Chen, Yen-Wen
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  givenname: Che-Sheng
  surname: Chu
  fullname: Chu, Che-Sheng
  organization: Department of Psychiatry, Kaohsiung Veterans General Hospital, Center for Geriatric and Gerontology, Kaohsiung Veterans General Hospital
– sequence: 2
  givenname: Ping-Tao
  orcidid: 0000-0001-5761-7800
  surname: Tseng
  fullname: Tseng, Ping-Tao
  organization: Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai’s Home, WinShine Clinics in Specialty of Psychiatry
– sequence: 3
  givenname: Brendon
  surname: Stubbs
  fullname: Stubbs, Brendon
  organization: Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, De Crespigny Park, Faculty of Health, Social Care and Education, Anglia Ruskin University
– sequence: 4
  givenname: Tien-Yu
  surname: Chen
  fullname: Chen, Tien-Yu
  organization: Department of Psychiatry, Tri-Service General Hospital; School of Medicine, National Defense Medical Center, Institute of Brain Science, National Yang-Ming University
– sequence: 5
  givenname: Chia-Hung
  surname: Tang
  fullname: Tang, Chia-Hung
  organization: Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare
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  givenname: Dian-Jeng
  orcidid: 0000-0002-6036-045X
  surname: Li
  fullname: Li, Dian-Jeng
  organization: Department of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Graduate institute of Medicine, College of Medicine, Kaohsiung Medical University
– sequence: 7
  givenname: Wei-Cheng
  surname: Yang
  fullname: Yang, Wei-Cheng
  organization: Department of Adult Psychiatry, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital
– sequence: 8
  givenname: Yen-Wen
  surname: Chen
  fullname: Chen, Yen-Wen
  organization: Prospect clinic for otorhinolaryngology & neurology
– sequence: 9
  givenname: Ching-Kuan
  surname: Wu
  fullname: Wu, Ching-Kuan
  organization: Center for Geriatric and Gerontology, Kaohsiung Veterans General Hospital
– sequence: 10
  givenname: Nicola
  surname: Veronese
  fullname: Veronese, Nicola
  organization: National Research Council, Neuroscience Institute, Aging Branch
– sequence: 11
  givenname: Andre F.
  surname: Carvalho
  fullname: Carvalho, Andre F.
  organization: Department of Psychiatry, University of Toronto, Centre for Addiction & Mental Health (CAMH)
– sequence: 12
  givenname: Brisa S.
  surname: Fernandes
  fullname: Fernandes, Brisa S.
  organization: IMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Deakin University, Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto
– sequence: 13
  givenname: Nathan
  surname: Herrmann
  fullname: Herrmann, Nathan
  organization: Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Psychiatry, University of Toronto
– sequence: 14
  givenname: Pao-Yen
  surname: Lin
  fullname: Lin, Pao-Yen
  email: py1029@adm.cgmh.org.tw
  organization: Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Institute for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29643479$$D View this record in MEDLINE/PubMed
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Alzheimer's disease
Cognitive ability
Dementia
Dementia disorders
Humanities and Social Sciences
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Meta-analysis
multidisciplinary
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Science (multidisciplinary)
Statins
Systematic review
Vascular dementia
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Title Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis
URI https://link.springer.com/article/10.1038/s41598-018-24248-8
https://www.ncbi.nlm.nih.gov/pubmed/29643479
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Volume 8
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