Assessment of skin barrier function using skin images with topological data analysis

• Published in: NPJ systems biology and applications Vol. 6; no. 1; pp. 40 - 9
• Main Authors: Koseki, Keita, Kawasaki, Hiroshi, Atsugi, Toru, Nakanishi, Miki, Mizuno, Makoto, Naru, Eiji, Ebihara, Tamotsu, Amagai, Masayuki, Kawakami, Eiryo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.12.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 639/705/1041; 639/705/1042; 692/699; 692/700; Adult; Bioinformatics; Biomedical and Life Sciences; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Data Analysis; Female; Humans; Image processing; Image Processing, Computer-Assisted - methods; Learning algorithms; Life Sciences; Machine Learning; Male; Phenotypes; Precision medicine; Skin - diagnostic imaging; Skin diseases; Skin Physiological Phenomena; Systems Biology; Water Loss, Insensible - physiology

Recent developments of molecular biology have revealed diverse mechanisms of skin diseases, and precision medicine considering these mechanisms requires the frequent objective evaluation of skin phenotypes. Transepidermal water loss (TEWL) is commonly used for evaluating skin barrier function; howev...