Parkinson’s disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical neurons

• Published in: NPJ Parkinson's Disease Vol. 8; no. 1; pp. 120 - 13
• Main Authors: Kochmanski, Joseph, Kuhn, Nathan C., Bernstein, Alison I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/2210; 631/378/1689/1718; 692/699/375/1718; Biomedical and Life Sciences; Biomedicine; DNA methylation; Epigenetics; Genomes; Neurology; Neurosciences; Parkinson's disease

Evidence for epigenetic regulation playing a role in Parkinson’s disease (PD) is growing, particularly for DNA methylation. Approximately 90% of PD cases are due to a complex interaction between age, genes, and environmental factors, and epigenetic marks are thought to mediate the relationship betwe...