Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

• Published in: Nature communications Vol. 9; no. 1; pp. 4004 - 18
• Main Authors: Hennrich, Marco L., Romanov, Natalie, Horn, Patrick, Jaeger, Samira, Eckstein, Volker, Steeples, Violetta, Ye, Fei, Ding, Ximing, Poisa-Beiro, Laura, Lai, Mang Ching, Lang, Benjamin, Boultwood, Jacqueline, Luft, Thomas, Zaugg, Judith B., Pellagatti, Andrea, Bork, Peer, Aloy, Patrick, Gavin, Anne-Claude, Ho, Anthony D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/91; 631/532/1542; 631/532/2074; 631/532/7; 82/58; Adult; Adult Stem Cells - cytology; Aging; Aging - genetics; Aging - metabolism; Aging - pathology; Animal models; Bone marrow; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Carbon - metabolism; Cells (biology); Cellular Senescence - genetics; Differentiation; Female; Gene Expression Profiling; Glycolysis; Hematopoiesis; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Homing; Humanities and Social Sciences; Humans; Intermediates; Male; Metabolism; Middle Aged; multidisciplinary; Niches; Progenitor cells; Proteins; Proteome; Proteomes; Regulators; Science; Science (multidisciplinary); Stem Cell Niche; Stem cell transplantation; Stem cells; Young Adult

Diminishing potential to replace damaged tissues is a hallmark for ageing of somatic stem cells, but the mechanisms remain elusive. Here, we present proteome-wide atlases of age-associated alterations in human haematopoietic stem and progenitor cells (HPCs) and five other cell populations that const...