Targeting TREM2 on tumor-associated macrophages enhances immunotherapy - Binnewies, Mikhail; Pollack, Joshua L.; Rudolph, Joshua; Dash, Subhadra; Abushawish, Marwan; Lee, Tian; Jahchan, Nadine S.; Canaday, Pamela; Lu, Erick; Norng, Manith; Mankikar, Shilpa; Liu, Victoria M.; et al. (Cell reports (Cambridge), 2021)
Keywords: afucosylation; Animals; Antineoplastic Agents, Immunological - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Line, Tumor; checkpoint; Coculture Techniques; Drug Resistance, Neoplasm; exhaustion; Female; glycoengineering; HEK293 Cells; Humans; Immune Checkpoint Inhibitors - pharmacology; immunosuppression; immunotherapy; Lymphocyte Activation - drug effects; Lymphocytes, Tumor-Infiltrating - drug effects; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Membrane Glycoproteins - antagonists & inhibitors; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; microenvironment; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - immunology; Programmed Cell Death 1 Receptor - metabolism; Receptors, Immunologic - antagonists & inhibitors; Receptors, Immunologic - metabolism; Signal Transduction; TAM; TREM2; Tumor Cells, Cultured; Tumor Microenvironment; tumor-associated macrophages; Tumor-Associated Macrophages - drug effects; Tumor-Associated Macrophages - immunology; Tumor-Associated Macrophages - metabolism; microenvironment; checkpoint; TAM; glycoengineering; immunotherapy; exhaustion; immunosuppression; TREM2; afucosylation; tumor-associated macrophages