RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability

• Published in: Scientific reports Vol. 7; no. 1; pp. 3470 - 12
• Main Authors: Alloza, Iraide, Goikuria, Haize, Idro, Juan Luis, Triviño, Juan Carlos, Fernández Velasco, José María, Elizagaray, Elena, García-Barcina, María, Montoya-Murillo, Genoveva, Sarasola, Esther, Vega Manrique, Reyes, Freijo, Maria del Mar, Vandenbroeck, Koen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.06.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 38/39; 45/90; 45/91; 631/337/2019; 692/4019; 692/53; 692/617; 82/29; Aged; Arteriosclerosis; Atherosclerosis; Biomarkers; Bone growth; Bone morphogenetic protein 2; Bone Morphogenetic Protein 2 - genetics; Bone Morphogenetic Protein 2 - metabolism; Carotid artery; Carotid Artery Diseases - genetics; Carotid Artery Diseases - metabolism; Carotid Artery Diseases - pathology; Cells, Cultured; Computational Biology - methods; Female; Gene expression; Gene Expression Profiling - methods; Gene Ontology; High-Throughput Nucleotide Sequencing; Humanities and Social Sciences; Humans; Isoforms; Male; Middle Aged; Molecular Sequence Annotation; multidisciplinary; Myocytes, Smooth Muscle - metabolism; Osteogenesis; Plaque, Atherosclerotic - genetics; Plaque, Atherosclerotic - metabolism; Plaque, Atherosclerotic - pathology; Plaques; Risk factors; Science; Science (multidisciplinary); Senescence; Smooth muscle; Transcriptome

Carotid artery atherosclerosis is a risk factor to develop cerebrovascular disease. Atheroma plaque can become instable and provoke a cerebrovascular event or else remain stable as asymptomatic type. The exact mechanism involved in plaque destabilization is not known but includes among other events...