A genetic engineering strategy for editing near-infrared-II fluorophores

• Published in: Nature communications Vol. 13; no. 1; p. 2853
• Main Authors: Tian, Rui, Feng, Xin, Wei, Long, Dai, Daoguo, Ma, Ying, Pan, Haifeng, Ge, Shengxiang, Bai, Lang, Ke, Chaomin, Liu, Yanlin, Lang, Lixin, Zhu, Shoujun, Sun, Haitao, Yu, Yanbao, Chen, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 59; 631/1647/245/2225; 639/638/309/436/1729; Albumin; Albumins; Biocompatibility; Bioengineering; Biological properties; Chemical compounds; Chemical synthesis; Contrast agents; Contrast media; Covalent bonds; Cyanine dyes; Dyes; Fluorescence; Fluorophores; Genetic engineering; Heavy metals; Humanities and Social Sciences; I.R. radiation; multidisciplinary; Near infrared radiation; Pharmacokinetics; Pharmacology; Probes; Proteins; Science; Science (multidisciplinary); Wavelength

The second near-infrared (NIR-II) window is a fundamental modality for deep-tissue in vivo imaging. However, it is challenging to synthesize NIR-II probes with high quantum yields (QYs), good biocompatibility, satisfactory pharmacokinetics, and tunable biological properties. Conventional long-wavele...