The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial
Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum ( CB ) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of CB in treating IBS is still unknown. This prospective,...
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| Published in | Scientific reports Vol. 8; no. 1; pp. 2964 - 11 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
14.02.2018
Nature Publishing Group |
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| Abstract | Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients.
Clostridium butyricum
(
CB
) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of
CB
in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of
CB
in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given
CB
or placebo for 4 weeks. End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency. Compared with placebo,
CB
is effective in improving the overall IBS-D symptoms (−62.12 ± 74.00 vs. −40.74 ± 63.67,
P
= 0.038) as well as quality of life (7.232 ± 14.06 vs. 3.159 ± 11.73,
P
= 0.032) and stool frequency (−1.602 ± 1.416 vs. −1.086 ± 1.644,
P
= 0.035). The responder rates are found higher in
CB
compared with the placebo (44.76% vs. 30.53%,
P
= 0.042). The change in fecal microbiota was analyzed and function pathways of
CB
in treating IBS-D were predicted. In conclusion,
CB
improves overall symptoms, quality of life and stool frequency in IBS-D patients and is considered to be used as a probiotics in treating IBS-D clinically. |
|---|---|
| AbstractList | Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients.
Clostridium butyricum
(
CB
) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of
CB
in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of
CB
in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given
CB
or placebo for 4 weeks. End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency. Compared with placebo,
CB
is effective in improving the overall IBS-D symptoms (−62.12 ± 74.00 vs. −40.74 ± 63.67,
P
= 0.038) as well as quality of life (7.232 ± 14.06 vs. 3.159 ± 11.73,
P
= 0.032) and stool frequency (−1.602 ± 1.416 vs. −1.086 ± 1.644,
P
= 0.035). The responder rates are found higher in
CB
compared with the placebo (44.76% vs. 30.53%,
P
= 0.042). The change in fecal microbiota was analyzed and function pathways of
CB
in treating IBS-D were predicted. In conclusion,
CB
improves overall symptoms, quality of life and stool frequency in IBS-D patients and is considered to be used as a probiotics in treating IBS-D clinically. Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum (CB) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of CB in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of CB in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given CB or placebo for 4 weeks. End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency. Compared with placebo, CB is effective in improving the overall IBS-D symptoms (-62.12 ± 74.00 vs. -40.74 ± 63.67, P = 0.038) as well as quality of life (7.232 ± 14.06 vs. 3.159 ± 11.73, P = 0.032) and stool frequency (-1.602 ± 1.416 vs. -1.086 ± 1.644, P = 0.035). The responder rates are found higher in CB compared with the placebo (44.76% vs. 30.53%, P = 0.042). The change in fecal microbiota was analyzed and function pathways of CB in treating IBS-D were predicted. In conclusion, CB improves overall symptoms, quality of life and stool frequency in IBS-D patients and is considered to be used as a probiotics in treating IBS-D clinically. Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum (CB) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of CB in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of CB in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given CB or placebo for 4 weeks. End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency. Compared with placebo, CB is effective in improving the overall IBS-D symptoms (−62.12 ± 74.00 vs. −40.74 ± 63.67, P = 0.038) as well as quality of life (7.232 ± 14.06 vs. 3.159 ± 11.73, P = 0.032) and stool frequency (−1.602 ± 1.416 vs. −1.086 ± 1.644, P = 0.035). The responder rates are found higher in CB compared with the placebo (44.76% vs. 30.53%, P = 0.042). The change in fecal microbiota was analyzed and function pathways of CB in treating IBS-D were predicted. In conclusion, CB improves overall symptoms, quality of life and stool frequency in IBS-D patients and is considered to be used as a probiotics in treating IBS-D clinically. Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum (CB) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of CB in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of CB in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given CB or placebo for 4 weeks. End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency. Compared with placebo, CB is effective in improving the overall IBS-D symptoms (-62.12 ± 74.00 vs. -40.74 ± 63.67, P = 0.038) as well as quality of life (7.232 ± 14.06 vs. 3.159 ± 11.73, P = 0.032) and stool frequency (-1.602 ± 1.416 vs. -1.086 ± 1.644, P = 0.035). The responder rates are found higher in CB compared with the placebo (44.76% vs. 30.53%, P = 0.042). The change in fecal microbiota was analyzed and function pathways of CB in treating IBS-D were predicted. In conclusion, CB improves overall symptoms, quality of life and stool frequency in IBS-D patients and is considered to be used as a probiotics in treating IBS-D clinically.Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum (CB) is a probiotics that has been used in several gastrointestinal diseases. The efficacy of CB in treating IBS is still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess the efficacy and safety of CB in treating diarrhea-predominant IBS (IBS-D) and analyze the fecal microbiota after treatment. Two hundred patients with IBS-D were recruited and were given CB or placebo for 4 weeks. End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency. Compared with placebo, CB is effective in improving the overall IBS-D symptoms (-62.12 ± 74.00 vs. -40.74 ± 63.67, P = 0.038) as well as quality of life (7.232 ± 14.06 vs. 3.159 ± 11.73, P = 0.032) and stool frequency (-1.602 ± 1.416 vs. -1.086 ± 1.644, P = 0.035). The responder rates are found higher in CB compared with the placebo (44.76% vs. 30.53%, P = 0.042). The change in fecal microbiota was analyzed and function pathways of CB in treating IBS-D were predicted. In conclusion, CB improves overall symptoms, quality of life and stool frequency in IBS-D patients and is considered to be used as a probiotics in treating IBS-D clinically. |
| ArticleNumber | 2964 |
| Author | Wang, Peng Li, Ming Li, Zhen Zhai, Wen-Zhe Sun, Yi-Yuan Li, Yue-Yue Li, Li-Xiang Yang, Xiao-Xiao Zuo, Xiu-Li Song, Li-Jin Li, Yan-Qing Gu, Xiang |
| Author_xml | – sequence: 1 givenname: Yi-Yuan surname: Sun fullname: Sun, Yi-Yuan organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 2 givenname: Ming surname: Li fullname: Li, Ming organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 3 givenname: Yue-Yue surname: Li fullname: Li, Yue-Yue organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 4 givenname: Li-Xiang surname: Li fullname: Li, Li-Xiang organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 5 givenname: Wen-Zhe surname: Zhai fullname: Zhai, Wen-Zhe organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 6 givenname: Peng surname: Wang fullname: Wang, Peng organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 7 givenname: Xiao-Xiao surname: Yang fullname: Yang, Xiao-Xiao organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 8 givenname: Xiang surname: Gu fullname: Gu, Xiang organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 9 givenname: Li-Jin surname: Song fullname: Song, Li-Jin organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 10 givenname: Zhen surname: Li fullname: Li, Zhen organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 11 givenname: Xiu-Li surname: Zuo fullname: Zuo, Xiu-Li organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University – sequence: 12 givenname: Yan-Qing surname: Li fullname: Li, Yan-Qing email: liyanqing@sdu.edu.cn organization: Department of Gastroenterology, Qilu Hospital, Shandong University, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29445178$$D View this record in MEDLINE/PubMed |
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| Snippet | Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients.
Clostridium butyricum
(
CB
) is... Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life of the patients. Clostridium butyricum (CB) is a... |
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| Title | The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial |
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