Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells

• Published in: Cell death & disease Vol. 12; no. 11; pp. 1055 - 14
• Main Authors: Wang, Chen, Zeng, Jie, Li, Li-Jie, Xue, Min, He, Si-Li
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.11.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/67/1517/1371; 692/699/67/1517/1371; Animals; Antibodies; Autophagy; Autophagy - drug effects; Autophagy - genetics; Biochemistry; Biomedical and Life Sciences; Carrier Proteins - metabolism; cdc25 Phosphatases - genetics; cdc25 Phosphatases - metabolism; Cell Biology; Cell Culture; Cell Line, Tumor; Cell viability; Cervical cancer; Cervix; Dephosphorylation; ErbB-2 protein; ErbB-3 protein; Female; Ferroptosis; Ferroptosis - drug effects; Ferroptosis - genetics; Fluorescence microscopy; Gene Expression Regulation, Neoplastic - drug effects; Humans; Immunology; Inhibitor drugs; Life Sciences; Male; Membrane Proteins - metabolism; Mice; Mice, Nude; Phagocytosis; Phosphorylation - drug effects; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction - drug effects; Sorafenib - pharmacology; Thyroid Hormone-Binding Proteins; Thyroid Hormones - metabolism; Transcription; Tumors; Up-Regulation - drug effects; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - pathology; Xenografts

Cervical cancer is the leading cause of cancer-related deaths in women, and treatment for cervical cancer is very limited. Emerging evidence suggests that targeting ferroptosis is a promising way to treat cancer. Here, we investigated the role of ferroptosis in cervical cancer, with a focus on the C...