The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression - Ma, Biao; Cheng, Hongcheng; Mu, Chenglong; Geng, Guangfeng; Zhao, Tian; Luo, Qian; Ma, Kaili; Chang, Rui; Liu, Qiangqiang; Gao, Ruize; Nie, Junli; Xie, Jiaying; et al. (Nature communications, 2019)
Keywords: 13; 631/67/2329; 631/67/327; 631/80/642/333; 631/80/86; Acidosis; Animals; Apoptosis; Apoptosis - drug effects; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Cancer; Cell death; Cell Death - drug effects; Cell Line, Tumor; Cellular Reprogramming; Clustered Regularly Interspaced Short Palindromic Repeats - genetics; Degradation; Disease Models, Animal; Environmental effects; FADD protein; Female; Gene expression; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Heterogeneity; Humanities and Social Sciences; Humans; Hypoxia; Hypoxia - metabolism; Immune response; Immune system; Lysine; Macrophages; Macrophages - drug effects; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microenvironments; Mitochondria; Mitochondria - drug effects; Mitochondria - genetics; multidisciplinary; Necrosis; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nuclear Respiratory Factor 1 - genetics; Nuclear Respiratory Factor 1 - metabolism; Polarization; Pyruvic acid; RNA, Small Interfering - genetics; Science; Science (multidisciplinary); Tumor cells; Tumor Microenvironment; Tumors; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination