Serotonin transporter functional polymorphisms potentially increase risk of schizophrenia separately and as a haplotype

• Published in: Scientific reports Vol. 12; no. 1; pp. 1336 - 9
• Main Authors: Ghamari, Rana, Yazarlou, Fatemeh, Khosravizadeh, Zahra, Moradkhani, Atefeh, Abdollahi, Elaheh, Alizadeh, Fatemeh
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 631/378; Adult; Alleles; Case-Control Studies; Etiology; Female; Females; Gel electrophoresis; Gene frequency; Genetic factors; Genotyping; Haplotypes; Humanities and Social Sciences; Humans; Linkage disequilibrium; Male; Mental disorders; Middle Aged; Minisatellite Repeats; Monoamine Oxidase - genetics; multidisciplinary; Polymerase chain reaction; Polymorphism, Single Nucleotide; Risk factors; Schizophrenia; Schizophrenia - genetics; Science; Science (multidisciplinary); Serotonin; Serotonin Plasma Membrane Transport Proteins - genetics; Serotonin transporter

Schizophrenia is a severe, disabling psychiatric disorder with unclear etiology. Family-based, twins, and adoption studies have shown that genetic factors have major contributions in schizophrenia occurrence. Until now, many studies have discovered the association of schizophrenia and its comorbid s...