Pre-operative Circulating Plasma Gelsolin Predicts Residual Disease and Detects Early Stage Ovarian Cancer

• Published in: Scientific reports Vol. 9; no. 1; pp. 13924 - 9
• Main Authors: Asare-Werehene, Meshach, Communal, Laudine, Carmona, Euridice, Le, Tien, Provencher, Diane, Mes-Masson, Anne-Marie, Tsang, Benjamin K.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.09.2019; Nature Publishing Group
• Subjects: 631/67/1517/1709; 631/67/1857; 82; Actin; Adult; Aged; Aged, 80 and over; Biomarkers; Biomarkers, Tumor - blood; Cell death; Cisplatin; Disease detection; Enzyme-linked immunosorbent assay; Female; Gelsolin; Gelsolin - blood; Humanities and Social Sciences; Humans; Medical prognosis; Middle Aged; multidisciplinary; Ovarian cancer; Ovarian Neoplasms - blood; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Patients; Preoperative Period; Regression analysis; Science; Science (multidisciplinary); Statistical analysis; Survival Analysis

Ovarian cancer (OVCA) patients with suboptimal residual disease (RD) and advanced stages have poor survival. pGSN is an actin binding protein which protects OVCA cells from cisplatin-induced death. There is an urgent need to discover reliable biomarkers to optimize individualized treatment recommend...