Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2 - Bracken, Colton J.; Lim, Shion A.; Solomon, Paige; Rettko, Nicholas J.; Nguyen, Duy P.; Zha, Beth Shoshana; Schaefer, Kaitlin; Byrnes, James R.; Zhou, Jie; Lui, Irene; Liu, Jia; Pance, Katarina; et al. (Nature chemical biology, 2021)
Keywords: 631/154/51; 631/250/255; 631/326/596/4130; 631/45/535; 631/92/469; ACE2; Affinity; Angiotensin; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - antagonists & inhibitors; Angiotensin-Converting Enzyme 2 - chemistry; Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - immunology; Animals; Antibodies; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - genetics; Antibodies, Neutralizing - immunology; Antibodies, Viral - chemistry; Antibodies, Viral - genetics; Antibodies, Viral - immunology; Binders; Binding sites; Binding Sites, Antibody - genetics; Binding Sites, Antibody - immunology; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Cell Biology; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Chlorocebus aethiops; COVID-19; Cryoelectron Microscopy; Epitopes; HEK293 Cells; Humans; Models, Molecular; Neutralization; Neutralizing; Peptide Library; Peptidyl-dipeptidase A; Phages; Prophylaxis; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Single-Chain Antibodies - chemistry; Single-Chain Antibodies - genetics; Single-Chain Antibodies - immunology; Spike Glycoprotein, Coronavirus - antagonists & inhibitors; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Vero Cells