Metabolic drug survey highlights cancer cell dependencies and vulnerabilities - Pemovska, Tea; Bigenzahn, Johannes W.; Srndic, Ismet; Lercher, Alexander; Bergthaler, Andreas; César-Razquin, Adrián; Kartnig, Felix; Kornauth, Christoph; Valent, Peter; Staber, Philipp B.; Superti-Furga, Giulio (Nature communications, 2021)
Keywords: 1-Phosphatidylinositol 3-kinase; 13; 13/1; 13/106; 13/44; 13/56; 38; 38/47; 49/98; 631/553/1833; 631/67/2327; 631/92/2132; 692/4028/67/1990/283; 82/80; Biology; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cell Survival - drug effects; Cell viability; Cluster Analysis; Clustering; Drugs; Fatty acids; Fatty Acids - biosynthesis; Fatty-acid synthase; Functional groups; Genotype; High-throughput screening; Humanities and Social Sciences; Humans; Interrogation; Leukemia; Leukemia, Myeloid - genetics; Leukemia, Myeloid - metabolism; Leukemia, Myeloid - pathology; Libraries; Metabolism; Monocarboxylic Acid Transporters - genetics; multidisciplinary; Myeloid leukemia; Nucleic acids; Oxidative stress; Perturbation; Phenotype; Phosphatidylinositol 3-Kinase - metabolism; Phosphoinositide-3 Kinase Inhibitors - metabolism; Phosphoinositide-3 Kinase Inhibitors - pharmacology; Pyrimidinones - metabolism; Pyrimidinones - pharmacology; Pyrrolidines - metabolism; Pyrrolidines - pharmacology; Science; Science (multidisciplinary); Screening; Signal Transduction; Small Molecule Libraries - classification; Small Molecule Libraries - metabolism; Small Molecule Libraries - pharmacology; Symporters - genetics; Systems Analysis; Thiophenes - metabolism; Thiophenes - pharmacology; TOR protein; Triazoles - metabolism; Triazoles - pharmacology; Tumor cell lines; Tumor Cells, Cultured