Emerging role of non‐coding RNA in health and disease

Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, the molecular arena at the microscopic level to study the mechanism, progressio...

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Published inMetabolic brain disease Vol. 36; no. 6; pp. 1119 - 1134
Main Authors Bhatti, Gurjit Kaur, Khullar, Naina, Sidhu, Inderpal Singh, Navik, Uma Shanker, Reddy, Arubala P., Reddy, P. Hemachandra, Bhatti, Jasvinder Singh
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2021
Springer Nature B.V
Subjects
Arteriosclerosis
Ataxia
Atherosclerosis
Atrophy
Biochemistry
Biomedical and Life Sciences
Biomedicine
Breast cancer
Cardiovascular diseases
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Cervical cancer
Chromatin remodeling
Coronary artery disease
Developmental disabilities
Dosage compensation
Drug development
Dystrophy
Epigenesis, Genetic - genetics
Epigenesis, Genetic - physiology
Epigenetics
Fibrosis
Genetic disorders
Genetics
Genomes
Genomic imprinting
Heart diseases
Humans
Humerus
Hypertension
Infectious diseases
Lung cancer
Metabolic Diseases
MicroRNAs - genetics
MicroRNAs - metabolism
Muscular dystrophy
Neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Neurology
Neuromuscular diseases
Neurosciences
Non-coding RNA
Oncology
Opitz syndrome
Post-translation
Proteomics
Review
Review Article
Ribonucleic acid
RNA
RNA Splicing - genetics
RNA Splicing - physiology
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Scapula
Spinal muscular atrophy
Technology transfer
Turf
Non‐coding RNA
miRNA
lncRNA
Genetic diseases
Neurodegenerative and cardiovascular diseases
Cancer
Online AccessGet full text
ISSN0885-7490
1573-7365
1573-7365
DOI10.1007/s11011-021-00739-y

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Abstract Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, the molecular arena at the microscopic level to study the mechanism, progression, and therapy is more rational and authentic pave than a macroscopic approach. Non-coding RNAs (ncRNAs) have now emerged as indispensable players in the diagnosis, development, and therapeutics of every abnormality concerning physiology, pathology, genetics, epigenetics, oncology, and developmental diseases. This is a comprehensive attempt to collate all the existing and proven strategies, techniques, mechanisms of genetic disorders including Silver Russell Syndrome, Fascio- scapula humeral muscular dystrophy, cardiovascular diseases (atherosclerosis, cardiac fibrosis, hypertension, etc.), neurodegenerative diseases (Spino-cerebral ataxia type 7, Spino-cerebral ataxia type 8, Spinal muscular atrophy, Opitz-Kaveggia syndrome, etc.) cancers (cervix, breast, lung cancer, etc.), and infectious diseases (viral) studied so far. This article encompasses discovery, biogenesis, classification, and evolutionary prospects of the existence of this junk RNA along with the integrated networks involving chromatin remodelling, dosage compensation, genome imprinting, splicing regulation, post-translational regulation and proteomics. In conclusion, all the major human diseases are discussed with a facilitated technology transfer, advancements, loopholes, and tentative future research prospects have also been proposed.
AbstractList Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, the molecular arena at the microscopic level to study the mechanism, progression, and therapy is more rational and authentic pave than a macroscopic approach. Non-coding RNAs (ncRNAs) have now emerged as indispensable players in the diagnosis, development, and therapeutics of every abnormality concerning physiology, pathology, genetics, epigenetics, oncology, and developmental diseases. This is a comprehensive attempt to collate all the existing and proven strategies, techniques, mechanisms of genetic disorders including Silver Russell Syndrome, Fascio- scapula humeral muscular dystrophy, cardiovascular diseases (atherosclerosis, cardiac fibrosis, hypertension, etc.), neurodegenerative diseases (Spino-cerebral ataxia type 7, Spino-cerebral ataxia type 8, Spinal muscular atrophy, Opitz-Kaveggia syndrome, etc.) cancers (cervix, breast, lung cancer, etc.), and infectious diseases (viral) studied so far. This article encompasses discovery, biogenesis, classification, and evolutionary prospects of the existence of this junk RNA along with the integrated networks involving chromatin remodelling, dosage compensation, genome imprinting, splicing regulation, post-translational regulation and proteomics. In conclusion, all the major human diseases are discussed with a facilitated technology transfer, advancements, loopholes, and tentative future research prospects have also been proposed.
Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, the molecular arena at the microscopic level to study the mechanism, progression, and therapy is more rational and authentic pave than a macroscopic approach. Non-coding RNAs (ncRNAs) have now emerged as indispensable players in the diagnosis, development, and therapeutics of every abnormality concerning physiology, pathology, genetics, epigenetics, oncology, and developmental diseases. This is a comprehensive attempt to collate all the existing and proven strategies, techniques, mechanisms of genetic disorders including Silver Russell Syndrome, Fascio- scapula humeral muscular dystrophy, cardiovascular diseases (atherosclerosis, cardiac fibrosis, hypertension, etc.), neurodegenerative diseases (Spino-cerebral ataxia type 7, Spino-cerebral ataxia type 8, Spinal muscular atrophy, Opitz-Kaveggia syndrome, etc.) cancers (cervix, breast, lung cancer, etc.), and infectious diseases (viral) studied so far. This article encompasses discovery, biogenesis, classification, and evolutionary prospects of the existence of this junk RNA along with the integrated networks involving chromatin remodelling, dosage compensation, genome imprinting, splicing regulation, post-translational regulation and proteomics. In conclusion, all the major human diseases are discussed with a facilitated technology transfer, advancements, loopholes, and tentative future research prospects have also been proposed.Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, the molecular arena at the microscopic level to study the mechanism, progression, and therapy is more rational and authentic pave than a macroscopic approach. Non-coding RNAs (ncRNAs) have now emerged as indispensable players in the diagnosis, development, and therapeutics of every abnormality concerning physiology, pathology, genetics, epigenetics, oncology, and developmental diseases. This is a comprehensive attempt to collate all the existing and proven strategies, techniques, mechanisms of genetic disorders including Silver Russell Syndrome, Fascio- scapula humeral muscular dystrophy, cardiovascular diseases (atherosclerosis, cardiac fibrosis, hypertension, etc.), neurodegenerative diseases (Spino-cerebral ataxia type 7, Spino-cerebral ataxia type 8, Spinal muscular atrophy, Opitz-Kaveggia syndrome, etc.) cancers (cervix, breast, lung cancer, etc.), and infectious diseases (viral) studied so far. This article encompasses discovery, biogenesis, classification, and evolutionary prospects of the existence of this junk RNA along with the integrated networks involving chromatin remodelling, dosage compensation, genome imprinting, splicing regulation, post-translational regulation and proteomics. In conclusion, all the major human diseases are discussed with a facilitated technology transfer, advancements, loopholes, and tentative future research prospects have also been proposed.
Author Navik, Uma Shanker
Khullar, Naina
Reddy, Arubala P.
Sidhu, Inderpal Singh
Bhatti, Gurjit Kaur
Reddy, P. Hemachandra
Bhatti, Jasvinder Singh
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  fullname: Khullar, Naina
  organization: Department of Zoology, Mata Gujri College
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  fullname: Sidhu, Inderpal Singh
  organization: Department of Zoology, Sri Guru Gobind Singh College
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  surname: Navik
  fullname: Navik, Uma Shanker
  organization: Department of Pharmacology, Central University of Punjab
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  fullname: Reddy, Arubala P.
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  fullname: Reddy, P. Hemachandra
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  organization: Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, Department of Internal Medicine, Texas Tech University Health Sciences Center, Departments of Neurology, School of Medicine, Texas Tech University Health Sciences Center, Public Health Department of Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Department of Speech, Language and Hearing Sciences, School Health Professions, Texas Tech University Health Sciences Center, Cell Biology & Biochemistry, Neuroscience & Pharmacology, Neurology, Public Health, School of Health Professions, Texas Tech University Health Sciences Center
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  surname: Bhatti
  fullname: Bhatti, Jasvinder Singh
  email: jasvinder.bhatti@cup.edu.in
  organization: Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab
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ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021
2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Copyright Springer Nature B.V. Aug 2021
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Issue 6
Keywords Non‐coding RNA
miRNA
lncRNA
Genetic diseases
Neurodegenerative and cardiovascular diseases
Cancer
Language English
License 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
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SubjectTerms Arteriosclerosis
Ataxia
Atherosclerosis
Atrophy
Biochemistry
Biomedical and Life Sciences
Biomedicine
Breast cancer
Cardiovascular diseases
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Cervical cancer
Chromatin remodeling
Coronary artery disease
Developmental disabilities
Dosage compensation
Drug development
Dystrophy
Epigenesis, Genetic - genetics
Epigenesis, Genetic - physiology
Epigenetics
Fibrosis
Genetic disorders
Genetics
Genomes
Genomic imprinting
Heart diseases
Humans
Humerus
Hypertension
Infectious diseases
Lung cancer
Metabolic Diseases
MicroRNAs - genetics
MicroRNAs - metabolism
Muscular dystrophy
Neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Neurology
Neuromuscular diseases
Neurosciences
Non-coding RNA
Oncology
Opitz syndrome
Post-translation
Proteomics
Review
Review Article
Ribonucleic acid
RNA
RNA Splicing - genetics
RNA Splicing - physiology
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Scapula
Spinal muscular atrophy
Technology transfer
Turf
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Title Emerging role of non‐coding RNA in health and disease
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