Inhibition of the CEBPβ-NFκB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an Alzheimer’s disease model - Yi-Bin, Wang; Xiang, Li; Bing, Yang; Qi, Zhang; Fei-Tong, Jiao; Minghong, Wang; Xiangxiang, Zhang; Le, Kang; Yan, Li; Ping, Sui; Yufei, Gao; Ye, Xu; et al. (Cell death & disease, 2022)
Keywords: 13/21; 13/31; 13/95; 14/19; 631/378/1689; 631/378/2612; 64/110; 82/51; 82/80; 96/2; 96/34; Abietanes; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - metabolism; Animals; Antibodies; Astrocytes; Bioavailability; Biochemistry; Biomedical and Life Sciences; Brain; CCAAT/enhancer-binding protein; Cell Biology; Cell Culture; Chromatin; Cognition; Cognitive ability; Disease Models, Animal; IL-1β; Immunology; Immunoprecipitation; Inflammation; Inflammation - drug therapy; Interleukin 6; Life Sciences; Mice; Mice, Transgenic; Microglia; Microglia - metabolism; Nanoparticles; Neurodegeneration; Neurodegenerative diseases; Neuroinflammatory Diseases; Neuronal-glial interactions; NF-κB protein; Oral administration; Presenilin 1; Signal transduction; Toxicity; Transcription; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; β-Amyloid; β-Cyclodextrin