Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

• Published in: Nature communications Vol. 9; no. 1; pp. 4860 - 17
• Main Authors: Hübner, Kathleen, Cabochette, Pauline, Diéguez-Hurtado, Rodrigo, Wiesner, Cora, Wakayama, Yuki, Grassme, Kathrin S., Hubert, Marvin, Guenther, Stefan, Belting, Heinz-Georg, Affolter, Markus, Adams, Ralf H., Vanhollebeke, Benoit, Herzog, Wiebke
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.11.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 14; 14/19; 38; 38/91; 42/70; 631/136/16; 631/136/334/1874/763; 631/378/1341; 64/116; 96; Anastomosis; Angiogenesis; Animals; Animals, Genetically Modified; Antigens, CD - genetics; Antigens, CD - metabolism; beta Catenin - genetics; beta Catenin - metabolism; Blood-brain barrier; Blood-Brain Barrier - growth & development; Blood-Brain Barrier - metabolism; Brain - blood supply; Brain - growth & development; Brain - metabolism; Cadherins; Cadherins - genetics; Cadherins - metabolism; Capillaries; Capillaries - growth & development; Capillaries - metabolism; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; Cell junctions; Central nervous system; Cerebrovascular Circulation - genetics; Embryo, Nonmammalian; Embryos; Gene Expression Regulation, Developmental; Genes, Reporter; Humanities and Social Sciences; Image resolution; Luminescent Proteins - genetics; Luminescent Proteins - metabolism; multidisciplinary; Neovascularization, Physiologic - genetics; Neurodegenerative diseases; Neuroimaging; Neurological diseases; Receptors, Lysosphingolipid - genetics; Receptors, Lysosphingolipid - metabolism; Red Fluorescent Protein; Science; Science (multidisciplinary); Signaling; Sphingosine 1-phosphate; Vascularization; Wnt protein; Wnt Signaling Pathway; Zebrafish - genetics; Zebrafish - growth & development; Zebrafish - metabolism; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; β-Catenin

Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain barrier (BBB) formation. BBB formation and modulation are not only important for development, but also relevant for vascular and neurodegenerative diseases. However, there is little understanding of...