Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

• Published in: Nature communications Vol. 10; no. 1; pp. 2461 - 12
• Main Authors: Gluck, Caroline, Qiu, Chengxiang, Han, Sang Youb, Palmer, Matthew, Park, Jihwan, Ko, Yi-An, Guan, Yuting, Sheng, Xin, Hanson, Robert L., Huang, Jing, Chen, Yong, Park, Ae Seo Deok, Izquierdo, Maria Concepcion, Mantzaris, Ioannis, Verma, Amit, Pullman, James, Li, Hongzhe, Susztak, Katalin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.06.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 45/22; 45/61; 45/77; 45/90; 631/208/176; 692/4022/1585/2759/1419; 692/699/1585/104; Aged; Case-Control Studies; CpG Islands; Cross-Sectional Studies; Cytosine; Cytosine - metabolism; Diabetes; Diabetes mellitus; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic nephropathy; Disease Progression; DNA Methylation; DNA probes; Epidermal growth factor; Epigenesis, Genetic; Female; Fibrosis; Gene expression; Gene Expression Regulation; Genomes; Glomerular Filtration Rate; Growth factors; Humanities and Social Sciences; Humans; Kidney - metabolism; Kidney - pathology; Kidney diseases; Kidneys; Male; Methylation; Middle Aged; multidisciplinary; Prediction models; Probes; Regulatory sequences; Renal function; Science; Science (multidisciplinary); Structural damage; Tubules

Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and v...