Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice

• Published in: Scientific reports Vol. 8; no. 1; pp. 3753 - 10
• Main Authors: Park, Min-Jung, Lee, Sung-Hee, Kim, Eun-Kyung, Lee, Eun-Jung, Baek, Jin-Ah, Park, Sung-Hwan, Kwok, Seung-Ki, Cho, Mi-La
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.02.2018; Nature Publishing Group
• Subjects: 13/21; 13/31; 13/51; 14/63; 631/250/1933; 631/250/38; 64/60; Animal models; Animals; Arginase - metabolism; Arthritis; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - metabolism; Autoimmune diseases; CD4 antigen; Cell Proliferation; Collagen; Forkhead Transcription Factors - metabolism; Foxp3 protein; Helper cells; Humanities and Social Sciences; Immunoregulation; Inflammation; Interleukin 10; Interleukin 17; Interleukin-10 - biosynthesis; Interleukin-10 - metabolism; Lymphocytes T; Male; Mice; multidisciplinary; Myeloid-Derived Suppressor Cells - cytology; Myeloid-Derived Suppressor Cells - metabolism; Progenitor cells; Rheumatoid arthritis; Science; Science (multidisciplinary); Stem cells; Suppressor cells; T-Lymphocytes, Regulatory - cytology; Th1 Cells - cytology; Th17 Cells - cytology

Myeloid-derived suppressor cells (MDSCs) are heterogenous populations of immature myeloid progenitor cells with immunoregulatory function. MDSCs play critical roles in controlling the processes of autoimmunity but their roles in rheumatoid arthritis (RA) are controversial. The present study was unde...